TY - JOUR
T1 - Continuous separation of magnetic beads using a Y-shaped microfluidic system integrated with hard-magnetic elements
AU - Sun, Jiajia
AU - Wu, Kai
AU - Su, Diqing
AU - Guo, Guannan
AU - Shi, Zongqian
N1 - Publisher Copyright:
© 2019 IOP Publishing Ltd.
PY - 2020
Y1 - 2020
N2 - A Y-shaped microfluidic separator with an array of hard-magnetic elements integrated in a non-magnetic substrate is designed to realize continuous separation of magnetic beads under an external bias field. By fixing the magnetization directions of the hard-magnetic elements parallel to the wall of microchannel, the spatial distribution of the magnetic field can be adjusted by the geometrical size of elements, the gap between two neighboring elements, and the direction of the external bias field. In this work, magnetic beads comprising of multiple magnetic/superparamagnetic nanoparticles (10 nm Fe5Si3, Fe3Si or Fe3O4) in polymer matrixes are used. Herein, Kelvin force on the magnetic bead is described by treating each magnetized superparamagnetic nanoparticle as an equivalent magnetic dipole. With the closed-form Kelvin force, a two-way model that takes bead-fluid interaction into account is adopted to investigate the trajectories of magnetic beads in our Y-shaped microfluidic system. Using the two-way model, the influence of the beads' size, the direction of the external bias field, the magnetic bead concentration and the bead-fluid interaction on the trajectories of magnetic beads is also investigated. 100% collection or separation efficiency can be realized just by adjusting inlet velocities. In addition, it is theoretically demonstrated that two kinds of magnetic beads with small size difference (down to 100 nm) can be successfully separated by using our Y-shaped microfluidic separator.
AB - A Y-shaped microfluidic separator with an array of hard-magnetic elements integrated in a non-magnetic substrate is designed to realize continuous separation of magnetic beads under an external bias field. By fixing the magnetization directions of the hard-magnetic elements parallel to the wall of microchannel, the spatial distribution of the magnetic field can be adjusted by the geometrical size of elements, the gap between two neighboring elements, and the direction of the external bias field. In this work, magnetic beads comprising of multiple magnetic/superparamagnetic nanoparticles (10 nm Fe5Si3, Fe3Si or Fe3O4) in polymer matrixes are used. Herein, Kelvin force on the magnetic bead is described by treating each magnetized superparamagnetic nanoparticle as an equivalent magnetic dipole. With the closed-form Kelvin force, a two-way model that takes bead-fluid interaction into account is adopted to investigate the trajectories of magnetic beads in our Y-shaped microfluidic system. Using the two-way model, the influence of the beads' size, the direction of the external bias field, the magnetic bead concentration and the bead-fluid interaction on the trajectories of magnetic beads is also investigated. 100% collection or separation efficiency can be realized just by adjusting inlet velocities. In addition, it is theoretically demonstrated that two kinds of magnetic beads with small size difference (down to 100 nm) can be successfully separated by using our Y-shaped microfluidic separator.
KW - FeSi
KW - FeSi
KW - hard-magnetic elements
KW - magnetic bead
KW - microfluidic separator
KW - superparamagnetic nanoparticle
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U2 - 10.1088/1361-6463/ab4fc8
DO - 10.1088/1361-6463/ab4fc8
M3 - Article
AN - SCOPUS:85075713386
SN - 0022-3727
VL - 53
JO - Journal of Physics D: Applied Physics
JF - Journal of Physics D: Applied Physics
IS - 3
M1 - 035004
ER -