TY - JOUR
T1 - Coordinate regulation of mRNA decay networks by GU-rich elements and CELF1
AU - Vlasova-St. Louis, Irina
AU - Bohjanen, Paul R.
N1 - Funding Information:
This work was supported by grant 1R01AI072068 from the National Institutes of Health .
PY - 2011/8
Y1 - 2011/8
N2 - The GU-rich element (GRE) was identified as a conserved sequence enriched in the 3' UTR of human transcripts that exhibited rapid mRNA turnover. In mammalian cells, binding to GREs by the protein CELF1 coordinates mRNA decay of networks of transcripts involved in cell growth, migration, and apoptosis. Depending on the context, GREs and CELF1 also regulate pre-mRNA splicing and translation. GREs are highly conserved throughout evolution and play important roles in the development of organisms ranging from worms to man. In humans, abnormal GRE-mediated regulation contributes to disease states and cancer. Thus, GREs and CELF proteins serve critical functions in gene expression regulation and define an important evolutionarily conserved posttranscriptional regulatory network.
AB - The GU-rich element (GRE) was identified as a conserved sequence enriched in the 3' UTR of human transcripts that exhibited rapid mRNA turnover. In mammalian cells, binding to GREs by the protein CELF1 coordinates mRNA decay of networks of transcripts involved in cell growth, migration, and apoptosis. Depending on the context, GREs and CELF1 also regulate pre-mRNA splicing and translation. GREs are highly conserved throughout evolution and play important roles in the development of organisms ranging from worms to man. In humans, abnormal GRE-mediated regulation contributes to disease states and cancer. Thus, GREs and CELF proteins serve critical functions in gene expression regulation and define an important evolutionarily conserved posttranscriptional regulatory network.
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U2 - 10.1016/j.gde.2011.03.002
DO - 10.1016/j.gde.2011.03.002
M3 - Review article
C2 - 21497082
AN - SCOPUS:79960919896
SN - 0959-437X
VL - 21
SP - 444
EP - 451
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 4
ER -
