Cross-linked iron oxide nanoparticles for therapeutic engineering and in vivo monitoring of mesenchymal stem cells in cerebral ischemia model

Ji Won Park; Sook Hee Ku; Hyung Ho Moon; Minhyung Lee; Donghoon Choi; Jaemoon Yang; Yong Min Huh; Ji Hoon Jeong; Tae Gwan Park; Hyejung Mok; Sun Hwa Kim

doi:10.1002/mabi.201300340

Cross-linked iron oxide nanoparticles for therapeutic engineering and in vivo monitoring of mesenchymal stem cells in cerebral ischemia model

Ji Won Park, Sook Hee Ku, Hyung Ho Moon, Minhyung Lee, Donghoon Choi, Jaemoon Yang, Yong Min Huh, Ji Hoon Jeong, Tae Gwan Park, Hyejung Mok, Sun Hwa Kim

Chemical Engineering and Materials Science

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area. Spherically cross-linked iron oxide nanoparticles (IONs) via catechol-grafted poly-L-lysine (PLL-DN) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) by magnet-mediated transfection of vascular endothelial growth factor plasmid DNA. They also enable monitoring of the MSC migration from injected site to ischemic region in rat cerebrovascular ischemia models via magnetic resonance (MR) imaging.

Original language	English (US)
Pages (from-to)	380-389
Number of pages	10
Journal	Macromolecular Bioscience
Volume	14
Issue number	3
DOIs	https://doi.org/10.1002/mabi.201300340
State	Published - Mar 2014

Keywords

cell engineering
cerebral ischemia model
cross-linked iron oxide nanoparticles
magnetic resonance imaging
mesenchymal stem cells

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title = "Cross-linked iron oxide nanoparticles for therapeutic engineering and in vivo monitoring of mesenchymal stem cells in cerebral ischemia model",

abstract = "Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area. Spherically cross-linked iron oxide nanoparticles (IONs) via catechol-grafted poly-L-lysine (PLL-DN) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) by magnet-mediated transfection of vascular endothelial growth factor plasmid DNA. They also enable monitoring of the MSC migration from injected site to ischemic region in rat cerebrovascular ischemia models via magnetic resonance (MR) imaging.",

keywords = "cell engineering, cerebral ischemia model, cross-linked iron oxide nanoparticles, magnetic resonance imaging, mesenchymal stem cells",

author = "Park, {Ji Won} and Ku, {Sook Hee} and Moon, {Hyung Ho} and Minhyung Lee and Donghoon Choi and Jaemoon Yang and Huh, {Yong Min} and Jeong, {Ji Hoon} and Park, {Tae Gwan} and Hyejung Mok and Kim, {Sun Hwa}",

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AU - Choi, Donghoon

AU - Yang, Jaemoon

AU - Huh, Yong Min

AU - Jeong, Ji Hoon

AU - Park, Tae Gwan

AU - Mok, Hyejung

AU - Kim, Sun Hwa

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AB - Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area. Spherically cross-linked iron oxide nanoparticles (IONs) via catechol-grafted poly-L-lysine (PLL-DN) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) by magnet-mediated transfection of vascular endothelial growth factor plasmid DNA. They also enable monitoring of the MSC migration from injected site to ischemic region in rat cerebrovascular ischemia models via magnetic resonance (MR) imaging.

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KW - cross-linked iron oxide nanoparticles

KW - magnetic resonance imaging

KW - mesenchymal stem cells

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Cross-linked iron oxide nanoparticles for therapeutic engineering and in vivo monitoring of mesenchymal stem cells in cerebral ischemia model

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