TY - JOUR
T1 - Cyanide antidotes for mass casualties
T2 - Water-soluble salts of the dithiane (sulfanegen) from 3-mercaptopyruvate for intramuscular administration
AU - Patterson, Steven E.
AU - Monteil, Alexandre R.
AU - Cohen, Jonathan F.
AU - Crankshaw, Daune L.
AU - Vince, Robert
AU - Nagasawa, Herbert T.
PY - 2013/2/14
Y1 - 2013/2/14
N2 - Current cyanide antidotes are administered by IV infusion, which is suboptimal for mass casualties. Therefore, in a cyanide disaster, intramuscular (IM) injectable antidotes would be more appropriate. We report the discovery of the highly water-soluble sulfanegen triethanolamine as a promising lead for development as an IM injectable cyanide antidote.
AB - Current cyanide antidotes are administered by IV infusion, which is suboptimal for mass casualties. Therefore, in a cyanide disaster, intramuscular (IM) injectable antidotes would be more appropriate. We report the discovery of the highly water-soluble sulfanegen triethanolamine as a promising lead for development as an IM injectable cyanide antidote.
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U2 - 10.1021/jm301633x
DO - 10.1021/jm301633x
M3 - Article
C2 - 23301495
AN - SCOPUS:84873905529
SN - 0022-2623
VL - 56
SP - 1346
EP - 1349
JO - Journal of medicinal chemistry
JF - Journal of medicinal chemistry
IS - 3
ER -