Cytokine and chemokine levels in patients infected with the novel avian influenza a (H7N9) virus in China

Ying Chi; Yefei Zhu; Tian Wen; Lunbiao Cui; Yiyue Ge; Yongjun Jiao; Tao Wu; Aihua Ge; Hong Ji; Ke Xu; Changjun Bao; Zheng Zhu; Xian Qi; Bin Wu; Zhiyang Shi; Fenyang Tang; Zheng Xing; Minghao Zhou

doi:10.1093/infdis/jit440

Cytokine and chemokine levels in patients infected with the novel avian influenza a (H7N9) virus in China

Ying Chi, Yefei Zhu, Tian Wen, Lunbiao Cui, Yiyue Ge, Yongjun Jiao, Tao Wu, Aihua Ge, Hong Ji, Ke Xu, Changjun Bao, Zheng Zhu, Xian Qi, Bin Wu, Zhiyang Shi, Fenyang Tang, Zheng Xing, Minghao Zhou

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A (H7N9) virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead immunoassays. Statistical analysis showed that IP-10, IL-6, IL-17, and IL-2 were increased in H7N9 infected patients. Furthermore, IL-6 and the chemokine IP-10 were significantly higher in severe H7N9 patients compared to nonsevere H7N9 cases. We suggest that proinflammatory cytokine responses, characterized by a combined Th1/Thl7 cytokine induction, are partially responsible for the disease progression of patients with H7N9 infection.

Original language	English (US)
Pages (from-to)	1962-1967
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	208
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jit440
State	Published - Dec 15 2013

Bibliographical note

Funding Information:
Financial support. This work was supported by National Major Science and Technology Projects for Infectious Disease Control and Prevention (2013ZX10004103-006), the Jiangsu Province Health Development Project with Science and Education (ZX201109, RC2011082, RC2011191, RC2011084, RC2011085, JKRC2011001) and the Science and Technology Pillar program of Jiangsu Province (BE2011796). Potential conflicts of interest. All authors: No reported conflicts.

Keywords

Chemokine
Cytokine
H7N9 avian influenza

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title = "Cytokine and chemokine levels in patients infected with the novel avian influenza a (H7N9) virus in China",

abstract = "H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A (H7N9) virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead immunoassays. Statistical analysis showed that IP-10, IL-6, IL-17, and IL-2 were increased in H7N9 infected patients. Furthermore, IL-6 and the chemokine IP-10 were significantly higher in severe H7N9 patients compared to nonsevere H7N9 cases. We suggest that proinflammatory cytokine responses, characterized by a combined Th1/Thl7 cytokine induction, are partially responsible for the disease progression of patients with H7N9 infection.",

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author = "Ying Chi and Yefei Zhu and Tian Wen and Lunbiao Cui and Yiyue Ge and Yongjun Jiao and Tao Wu and Aihua Ge and Hong Ji and Ke Xu and Changjun Bao and Zheng Zhu and Xian Qi and Bin Wu and Zhiyang Shi and Fenyang Tang and Zheng Xing and Minghao Zhou",

note = "Funding Information: Financial support. This work was supported by National Major Science and Technology Projects for Infectious Disease Control and Prevention (2013ZX10004103-006), the Jiangsu Province Health Development Project with Science and Education (ZX201109, RC2011082, RC2011191, RC2011084, RC2011085, JKRC2011001) and the Science and Technology Pillar program of Jiangsu Province (BE2011796). Potential conflicts of interest. All authors: No reported conflicts.",

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AU - Chi, Ying

AU - Zhu, Yefei

AU - Wen, Tian

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AU - Ge, Yiyue

AU - Jiao, Yongjun

AU - Wu, Tao

AU - Ge, Aihua

AU - Ji, Hong

AU - Xu, Ke

AU - Bao, Changjun

AU - Zhu, Zheng

AU - Qi, Xian

AU - Wu, Bin

AU - Shi, Zhiyang

AU - Tang, Fenyang

AU - Xing, Zheng

AU - Zhou, Minghao

N1 - Funding Information: Financial support. This work was supported by National Major Science and Technology Projects for Infectious Disease Control and Prevention (2013ZX10004103-006), the Jiangsu Province Health Development Project with Science and Education (ZX201109, RC2011082, RC2011191, RC2011084, RC2011085, JKRC2011001) and the Science and Technology Pillar program of Jiangsu Province (BE2011796). Potential conflicts of interest. All authors: No reported conflicts.

PY - 2013/12/15

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N2 - H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A (H7N9) virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead immunoassays. Statistical analysis showed that IP-10, IL-6, IL-17, and IL-2 were increased in H7N9 infected patients. Furthermore, IL-6 and the chemokine IP-10 were significantly higher in severe H7N9 patients compared to nonsevere H7N9 cases. We suggest that proinflammatory cytokine responses, characterized by a combined Th1/Thl7 cytokine induction, are partially responsible for the disease progression of patients with H7N9 infection.

AB - H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A (H7N9) virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead immunoassays. Statistical analysis showed that IP-10, IL-6, IL-17, and IL-2 were increased in H7N9 infected patients. Furthermore, IL-6 and the chemokine IP-10 were significantly higher in severe H7N9 patients compared to nonsevere H7N9 cases. We suggest that proinflammatory cytokine responses, characterized by a combined Th1/Thl7 cytokine induction, are partially responsible for the disease progression of patients with H7N9 infection.

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KW - Cytokine

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Cytokine and chemokine levels in patients infected with the novel avian influenza a (H7N9) virus in China

Abstract

Bibliographical note

Keywords

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