Cytotoxic simplified tubulysin analogues

Bhooma Raghavan; Ranganathan Balasubramanian; Jaeson C. Steele; Dan L. Sackett; Robert A. Fecik

doi:10.1021/jm701321p

Cytotoxic simplified tubulysin analogues

Bhooma Raghavan, Ranganathan Balasubramanian, Jaeson C. Steele, Dan L. Sackett, Robert A. Fecik

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

An efficient route for the synthesis of the tubulysin family of antimitotic peptides was developed. Simplified tubulysin analogues were synthesized to define the minimum pharmacophore required for cytotoxicity. Simplified tubulysin analogues retain significant cytotoxicity and reveal important preliminary structure-activity relationships.

Original language	English (US)
Pages (from-to)	1530-1533
Number of pages	4
Journal	Journal of medicinal chemistry
Volume	51
Issue number	6
DOIs	https://doi.org/10.1021/jm701321p
State	Published - Mar 27 2008

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title = "Cytotoxic simplified tubulysin analogues",

abstract = "An efficient route for the synthesis of the tubulysin family of antimitotic peptides was developed. Simplified tubulysin analogues were synthesized to define the minimum pharmacophore required for cytotoxicity. Simplified tubulysin analogues retain significant cytotoxicity and reveal important preliminary structure-activity relationships.",

author = "Bhooma Raghavan and Ranganathan Balasubramanian and Steele, {Jaeson C.} and Sackett, {Dan L.} and Fecik, {Robert A.}",

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AU - Raghavan, Bhooma

AU - Balasubramanian, Ranganathan

AU - Steele, Jaeson C.

AU - Sackett, Dan L.

AU - Fecik, Robert A.

PY - 2008/3/27

Y1 - 2008/3/27

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Cytotoxic simplified tubulysin analogues

Abstract

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