Dehydroepiandrosterone and related steroids inhibit mitochondrial respiration in vitro

Pamarthi F. Mohan; Margot P. Cleary

doi:10.1016/0020-711X(89)90050-5

Dehydroepiandrosterone and related steroids inhibit mitochondrial respiration in vitro

Pamarthi F. Mohan, Margot P. Cleary

Hormel Institute

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Abstract

1. 1. Dehydroepiandrosterone (DHEA) inhibited mitochondrial respiratory rates in the presence of tricarboxylic acid cycle intermediates with the exception of succinate. 2. 2. Several other steroids tested for inhibitory activity on mitochondrial state 3 rate showed inhibitory potencies ranging from 0-90%. 3. 3. Mitochondria isolated from adrenals, heart, kidneys, brain and brown adipose tissue were also inhibited by DHEA. 4. 4. The aspartate-malate shuttle system was inhibited, but the α-glycerophosphate shuttle was totally insensitive to DHEA. 5. 5. The high-amplitude swelling of mitochondria in hypotonic media was inhibited by DHEA and a few other steroids.

Original language	English (US)
Pages (from-to)	1103-1107
Number of pages	5
Journal	International Journal of Biochemistry
Volume	21
Issue number	10
DOIs	https://doi.org/10.1016/0020-711X(89)90050-5
State	Published - 1989

Bibliographical note

Funding Information:
Acknowledgemenfs-This work was supported by United States Public Health Service Grant HL08214 from the Program Projects Branch, Extramural Programs, National Heart, Lung and Blood Institute, and by The Hormel Foundation.

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abstract = "1. 1. Dehydroepiandrosterone (DHEA) inhibited mitochondrial respiratory rates in the presence of tricarboxylic acid cycle intermediates with the exception of succinate. 2. 2. Several other steroids tested for inhibitory activity on mitochondrial state 3 rate showed inhibitory potencies ranging from 0-90%. 3. 3. Mitochondria isolated from adrenals, heart, kidneys, brain and brown adipose tissue were also inhibited by DHEA. 4. 4. The aspartate-malate shuttle system was inhibited, but the α-glycerophosphate shuttle was totally insensitive to DHEA. 5. 5. The high-amplitude swelling of mitochondria in hypotonic media was inhibited by DHEA and a few other steroids.",

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AB - 1. 1. Dehydroepiandrosterone (DHEA) inhibited mitochondrial respiratory rates in the presence of tricarboxylic acid cycle intermediates with the exception of succinate. 2. 2. Several other steroids tested for inhibitory activity on mitochondrial state 3 rate showed inhibitory potencies ranging from 0-90%. 3. 3. Mitochondria isolated from adrenals, heart, kidneys, brain and brown adipose tissue were also inhibited by DHEA. 4. 4. The aspartate-malate shuttle system was inhibited, but the α-glycerophosphate shuttle was totally insensitive to DHEA. 5. 5. The high-amplitude swelling of mitochondria in hypotonic media was inhibited by DHEA and a few other steroids.

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Dehydroepiandrosterone and related steroids inhibit mitochondrial respiration in vitro

Abstract

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