TY - JOUR
T1 - Delayed peripheral venous catheter-related Staphylococcus aureus bacteremia
T2 - Onset ≥24 hours after catheter removal
AU - Sanchez, Kathryn T.
AU - Obeid, Karam M.
AU - Szpunar, Susan
AU - Fakih, Mohamad G.
AU - Khatib, Riad
N1 - Funding Information:
The study was supported by St. Medical Education Fund.
PY - 2012/7
Y1 - 2012/7
N2 - Peripheral venous catheter (PVC)-associated bacteremia usually develops during the indwelling period. We present a review of 14 patients who developed delayed onset Staphylococcus aureus bacteremia (D-SAB), 16 days after PVC removal, and compare them to 29 patients with early onset PVC-related S. aureus bacteremia (E-SAB). At the time of removal, the catheter site exhibited inflammation in 8 (57.1%) cases. At SAB onset, PVC site inflammation developed in all patients. Compared to E-SAB, patients with D-SAB were more often aged ≥65 y (71.4% vs. 34.5%; p 0.03) and on corticosteroids (35.7% vs. 6.9%; p 0.02). D-SAB was more complicated with persistent (>3 days) bacteremia (42.9% vs. 13.8%; p 0.04), metastatic infections (35.7% vs. 6.9%; p 0.02), and slightly higher mortality (21.4% vs. 10.3%; p 0.3). Logistic regression revealed that the predictors of D-SAB were corticosteroids (odds ratio (OR) 2.10, 95% confidence intervals (CI) 1.1658.61) and age ≥65 y (OR 1.63, 95% CI 1.1223.30). These patients may have impaired local/systemic defenses that lead to D-SAB, or a blunted host response with delayed recognition.
AB - Peripheral venous catheter (PVC)-associated bacteremia usually develops during the indwelling period. We present a review of 14 patients who developed delayed onset Staphylococcus aureus bacteremia (D-SAB), 16 days after PVC removal, and compare them to 29 patients with early onset PVC-related S. aureus bacteremia (E-SAB). At the time of removal, the catheter site exhibited inflammation in 8 (57.1%) cases. At SAB onset, PVC site inflammation developed in all patients. Compared to E-SAB, patients with D-SAB were more often aged ≥65 y (71.4% vs. 34.5%; p 0.03) and on corticosteroids (35.7% vs. 6.9%; p 0.02). D-SAB was more complicated with persistent (>3 days) bacteremia (42.9% vs. 13.8%; p 0.04), metastatic infections (35.7% vs. 6.9%; p 0.02), and slightly higher mortality (21.4% vs. 10.3%; p 0.3). Logistic regression revealed that the predictors of D-SAB were corticosteroids (odds ratio (OR) 2.10, 95% confidence intervals (CI) 1.1658.61) and age ≥65 y (OR 1.63, 95% CI 1.1223.30). These patients may have impaired local/systemic defenses that lead to D-SAB, or a blunted host response with delayed recognition.
KW - Bacteremia
KW - Peripheral venous catheter
KW - Staphylococcus aureus
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U2 - 10.3109/00365548.2012.669841
DO - 10.3109/00365548.2012.669841
M3 - Article
C2 - 22497345
AN - SCOPUS:84862570144
SN - 0036-5548
VL - 44
SP - 551
EP - 554
JO - Scandinavian Journal of Infectious Diseases
JF - Scandinavian Journal of Infectious Diseases
IS - 7
ER -