Design and in situ characterization of lipid containers with enhanced drug retention

Benjamin Wong; Cecile Boyer; Christian Steinbeck; David Peters; Jason Schmidt; Ryan Van Zanten; Bradley Chmelka; Joseph A. Zasadzinski

doi:10.1002/adma.201003578

Design and in situ characterization of lipid containers with enhanced drug retention

Benjamin Wong, Cecile Boyer, Christian Steinbeck, David Peters, Jason Schmidt, Ryan Van Zanten, Bradley Chmelka, Joseph A. Zasadzinski

Chemical Engineering and Materials Science

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Vesosome with distinct interior (green, orange) and exterior (blue) bilayer membranes. Drugs are encapsulated within the interior compartments and are protected from blood serum components by the exterior membrane. The outer membrane can be decorated with PEG lipids (red) to prevent aggregation in the blood as well as specific labels or targeting ligands.

Original language	English (US)
Pages (from-to)	2320-2325
Number of pages	6
Journal	Advanced Materials
Volume	23
Issue number	20
DOIs	https://doi.org/10.1002/adma.201003578
State	Published - May 24 2011

Keywords

F PGSE NMR
H PGSE NMR
ciprofloxacin
drug delivery
liposomes
vesicles

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title = "Design and in situ characterization of lipid containers with enhanced drug retention",

abstract = "Vesosome with distinct interior (green, orange) and exterior (blue) bilayer membranes. Drugs are encapsulated within the interior compartments and are protected from blood serum components by the exterior membrane. The outer membrane can be decorated with PEG lipids (red) to prevent aggregation in the blood as well as specific labels or targeting ligands.",

keywords = "F PGSE NMR, H PGSE NMR, ciprofloxacin, drug delivery, liposomes, vesicles",

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AU - Wong, Benjamin

AU - Boyer, Cecile

AU - Steinbeck, Christian

AU - Peters, David

AU - Schmidt, Jason

AU - Van Zanten, Ryan

AU - Chmelka, Bradley

AU - Zasadzinski, Joseph A.

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AB - Vesosome with distinct interior (green, orange) and exterior (blue) bilayer membranes. Drugs are encapsulated within the interior compartments and are protected from blood serum components by the exterior membrane. The outer membrane can be decorated with PEG lipids (red) to prevent aggregation in the blood as well as specific labels or targeting ligands.

KW - F PGSE NMR

KW - H PGSE NMR

KW - ciprofloxacin

KW - drug delivery

KW - liposomes

KW - vesicles

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Design and in situ characterization of lipid containers with enhanced drug retention

Abstract

Keywords

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