TY - JOUR
T1 - Designer microbes for biosynthesis
AU - Quin, Maureen B.
AU - Schmidt-Dannert, Claudia
N1 - Funding Information:
The authors gratefully acknowledge support by the National Institute of Health (grant GM080299 , to CSD).
PY - 2014/10
Y1 - 2014/10
N2 - Microbes have long been adapted for the biosynthetic production of useful compounds. There is increasing demand for the rapid and cheap microbial production of diverse molecules in an industrial setting. Microbes can now be designed and engineered for a particular biosynthetic purpose, thanks to recent developments in genome sequencing, metabolic engineering, and synthetic biology. Advanced tools exist for the genetic manipulation of microbes to create novel metabolic circuits, making new products accessible. Metabolic processes can be optimized to increase yield and balance pathway flux. Progress is being made towards the design and creation of fully synthetic microbes for biosynthetic purposes. Together, these emerging technologies will facilitate the production of designer microbes for biosynthesis.
AB - Microbes have long been adapted for the biosynthetic production of useful compounds. There is increasing demand for the rapid and cheap microbial production of diverse molecules in an industrial setting. Microbes can now be designed and engineered for a particular biosynthetic purpose, thanks to recent developments in genome sequencing, metabolic engineering, and synthetic biology. Advanced tools exist for the genetic manipulation of microbes to create novel metabolic circuits, making new products accessible. Metabolic processes can be optimized to increase yield and balance pathway flux. Progress is being made towards the design and creation of fully synthetic microbes for biosynthetic purposes. Together, these emerging technologies will facilitate the production of designer microbes for biosynthesis.
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U2 - 10.1016/j.copbio.2014.02.014
DO - 10.1016/j.copbio.2014.02.014
M3 - Review article
C2 - 24646570
AN - SCOPUS:84896137466
SN - 0958-1669
VL - 29
SP - 55
EP - 61
JO - Current opinion in biotechnology
JF - Current opinion in biotechnology
IS - 1
ER -