Desmethylubiquinone Q 2 from the Far-Eastern ascidian Aplidium glabrum: Structure and synthesis

Larisa K. Shubina; Sergey N. Fedorov; Oleg S. Radchenko; Nadezhda N. Balaneva; Sophia A. Kolesnikova; Pavel S. Dmitrenok; Ann Bode; Zigang Dong; Valentin A. Stonik

doi:10.1016/j.tetlet.2004.11.157

Desmethylubiquinone Q ₂ from the Far-Eastern ascidian Aplidium glabrum: Structure and synthesis

Larisa K. Shubina, Sergey N. Fedorov, Oleg S. Radchenko, Nadezhda N. Balaneva, Sophia A. Kolesnikova, Pavel S. Dmitrenok, Ann Bode, Zigang Dong, Valentin A. Stonik

Hormel Institute

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Two new diprenylquinones, glabruquinone A (desmethylubiquinone Q ₂) having cancer preventive properties and its minor isomer Glabruquinone B were isolated from the ascidian Aplidium glabrum. Their structures have been elucidated by NMR and mass spectra and confirmed by synthesis.

Original language	English (US)
Pages (from-to)	559-562
Number of pages	4
Journal	Tetrahedron Letters
Volume	46
Issue number	4
DOIs	https://doi.org/10.1016/j.tetlet.2004.11.157
State	Published - Jan 24 2005

Bibliographical note

Funding Information:
We are grateful to B. B. Grebnev for identification of the ascidian. The research described in this publication was made possible in part by Grant NS-725.2003.4 of RFBR and a Grant from the Program ‘Molecular and cell biology of RAS’.

Keywords

Cancer preventive activity
Marine natural products
Polyprenylated quinones
Synthesis

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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abstract = "Two new diprenylquinones, glabruquinone A (desmethylubiquinone Q 2) having cancer preventive properties and its minor isomer Glabruquinone B were isolated from the ascidian Aplidium glabrum. Their structures have been elucidated by NMR and mass spectra and confirmed by synthesis.",

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AU - Dmitrenok, Pavel S.

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AU - Dong, Zigang

AU - Stonik, Valentin A.

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