Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action

Emily S. Pfeiffer; Hiroshi Hiasa

doi:10.1128/AAC.00362-07

Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action

Emily S. Pfeiffer, Hiroshi Hiasa

Pharmacology

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12 Scopus citations

Abstract

We used an assay to measure quinolone sensitivity as a shift in the position of the cleavage-religation equilibrium. This assay was found to be useful in identifying the primary target of a quinolone drug and assessing the effect of quinolone resistance-conferring mutations.

Original language	English (US)
Pages (from-to)	3410-3412
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	51
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00362-07
State	Published - Sep 2007

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abstract = "We used an assay to measure quinolone sensitivity as a shift in the position of the cleavage-religation equilibrium. This assay was found to be useful in identifying the primary target of a quinolone drug and assessing the effect of quinolone resistance-conferring mutations.",

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Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action

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