TY - JOUR
T1 - Development and validation of 3D MP-SSFP to enable MRI in inhomogeneous magnetic fields
AU - Kobayashi, Naoharu
AU - Parkinson, Ben
AU - Idiyatullin, Djaudat
AU - Adriany, Gregor
AU - Theilenberg, Sebastian
AU - Juchem, Christoph
AU - Garwood, Michael
N1 - Publisher Copyright:
© 2020 International Society for Magnetic Resonance in Medicine
PY - 2021/2/1
Y1 - 2021/2/1
N2 - Purpose: We demonstrate the feasibility of MRI with missing-pulse steady-state free precession (MP-SSFP) in a 4T magnet with artificially degraded homogeneity. Methods: T1, T2, and diffusion contrast of MP-SSFP was simulated with constant and alternate radiofrequency (RF) phase using an extended phase graph. To validate MP-SSFP performance in human brain imaging, MP-SSFP was tested with two types of artificially introduced inhomogeneous magnetic fields: (1) a pure linear gradient field, and (2) a pseudo-linear gradient field introduced by mounting a head-gradient set at 36 cm from the magnet isocenter. Image distortion induced by the nonlinear inhomogeneous field was corrected using B0 mapping measured with MP-SSFP. Results: The maximum flip angle in MP-SSFP was limited to ≤10° because of the large range of resonance frequencies in the inhomogeneous magnetic fields tested in this study. Under this flip-angle limitation, MP-SSFP with constant RF phase provided advantages of higher signal-to-noise ratio and insensitivity to B1+ field inhomogeneity as compared with an alternate RF phase. In diffusion simulation, the steady-state magnetization in constant RF phase MP-SSFP increased with an increase of static field gradient up to 8 to 21 mT/m depending on simulation parameters. Experimental results at 4T validated these findings. In human brain imaging, MP-SSFP preserved sufficient signal intensities, but images showed severe image distortion from the pseudo-linear inhomogeneous field. However, following distortion correction, good-quality brain images were achieved. Conclusion: MP-SSFP appears to be a feasible MRI technique for brain imaging in an inhomogeneous magnetic field.
AB - Purpose: We demonstrate the feasibility of MRI with missing-pulse steady-state free precession (MP-SSFP) in a 4T magnet with artificially degraded homogeneity. Methods: T1, T2, and diffusion contrast of MP-SSFP was simulated with constant and alternate radiofrequency (RF) phase using an extended phase graph. To validate MP-SSFP performance in human brain imaging, MP-SSFP was tested with two types of artificially introduced inhomogeneous magnetic fields: (1) a pure linear gradient field, and (2) a pseudo-linear gradient field introduced by mounting a head-gradient set at 36 cm from the magnet isocenter. Image distortion induced by the nonlinear inhomogeneous field was corrected using B0 mapping measured with MP-SSFP. Results: The maximum flip angle in MP-SSFP was limited to ≤10° because of the large range of resonance frequencies in the inhomogeneous magnetic fields tested in this study. Under this flip-angle limitation, MP-SSFP with constant RF phase provided advantages of higher signal-to-noise ratio and insensitivity to B1+ field inhomogeneity as compared with an alternate RF phase. In diffusion simulation, the steady-state magnetization in constant RF phase MP-SSFP increased with an increase of static field gradient up to 8 to 21 mT/m depending on simulation parameters. Experimental results at 4T validated these findings. In human brain imaging, MP-SSFP preserved sufficient signal intensities, but images showed severe image distortion from the pseudo-linear inhomogeneous field. However, following distortion correction, good-quality brain images were achieved. Conclusion: MP-SSFP appears to be a feasible MRI technique for brain imaging in an inhomogeneous magnetic field.
KW - brain imaging
KW - inhomogeneous magnetic field
KW - missing pulse steady-state free precession
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U2 - 10.1002/mrm.28469
DO - 10.1002/mrm.28469
M3 - Article
C2 - 32892400
AN - SCOPUS:85090215677
SN - 0740-3194
VL - 85
SP - 831
EP - 844
JO - Magnetic resonance in medicine
JF - Magnetic resonance in medicine
IS - 2
ER -