TY - JOUR
T1 - Development, ontogeny, and maintenance of TCRαβ+ CD8αα IEL
AU - Ruscher, Roland
AU - Hogquist, Kristin A.
N1 - Publisher Copyright:
© 2019 Elsevier Ltd
PY - 2019/6
Y1 - 2019/6
N2 - The intestinal epithelium is the outermost cellular layer that separates the body from the gut lumen. The integrity of this protective mucosal barrier is crucial and maintained by specialized cells—intraepithelial lymphocytes (IEL). Much research has been conducted on these cells and our overall understanding of them is increasing rapidly. In this review we focus on the TCRαβ+ subset of CD8αα IEL. We discuss recent studies that shed light on the development, ontogeny, maintenance, and functional characteristics of CD8αα IEL, and highlight yet unanswered questions for future studies.
AB - The intestinal epithelium is the outermost cellular layer that separates the body from the gut lumen. The integrity of this protective mucosal barrier is crucial and maintained by specialized cells—intraepithelial lymphocytes (IEL). Much research has been conducted on these cells and our overall understanding of them is increasing rapidly. In this review we focus on the TCRαβ+ subset of CD8αα IEL. We discuss recent studies that shed light on the development, ontogeny, maintenance, and functional characteristics of CD8αα IEL, and highlight yet unanswered questions for future studies.
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U2 - 10.1016/j.coi.2019.04.010
DO - 10.1016/j.coi.2019.04.010
M3 - Review article
C2 - 31146182
AN - SCOPUS:85066114421
SN - 0952-7915
VL - 58
SP - 83
EP - 88
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
ER -