Diagnosis of posttraumatic stress disorder (PTSD) based on correlations of prewhitened fMRI data: outcomes and areas involved

Peka Christova; Lisa M James; Brian Engdahl; Scott M. Lewis; Apostolos P Georgopoulos

doi:10.1007/s00221-015-4339-0

Diagnosis of posttraumatic stress disorder (PTSD) based on correlations of prewhitened fMRI data: outcomes and areas involved

Peka Christova, Lisa M James, Brian Engdahl, Scott M. Lewis, Apostolos P Georgopoulos

Neuroscience

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Successful diagnosis of PTSD has been achieved using neural correlations from prewhitened magnetoencephalographic (MEG) time series (Georgopoulos et al. in J Neural Eng 7:16011, 2010. doi:10.1088/1741-2560/7/1/016011; James et al. 2015). Here, we show that highly successful classification of PTSD and control subjects can be obtained using neural correlations from prewhitened resting-state fMRI data. All but one PTSD (14/15; sensitivity = 93.3 %) and all but one control (20/21; specificity = 95.2 %) subjects were correctly classified using 15 out of 2701 possible correlations between 74 brain areas. In contrast, correlations of the same but non-prewhitened data yielded chance-level classifications. We conclude that, if properly processed, fMRI has the prospect of aiding significantly in PTSD diagnosis. Twenty-five brain areas were most prominently involved in correct subject classification, including areas from all cortical lobes and the left pallidum.

Original language	English (US)
Pages (from-to)	2695-2705
Number of pages	11
Journal	Experimental Brain Research
Volume	233
Issue number	9
DOIs	https://doi.org/10.1007/s00221-015-4339-0
State	Published - Sep 18 2015

Bibliographical note

Funding Information:
This study was supported by a Service Directed grant from the US Department of Veterans Affairs, the University of Minnesota American Legion Brain Sciences Chair (A.P.G.), and the University of Minnesota Anderson Chair for PTSD Research (B.E.).

Publisher Copyright:
© 2015, Springer-Verlag Berlin Heidelberg (outside the USA).

Keywords

Biomarkers
PTSD
Prewhitening
fMRI classification

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title = "Diagnosis of posttraumatic stress disorder (PTSD) based on correlations of prewhitened fMRI data: outcomes and areas involved",

abstract = "Successful diagnosis of PTSD has been achieved using neural correlations from prewhitened magnetoencephalographic (MEG) time series (Georgopoulos et al. in J Neural Eng 7:16011, 2010. doi:10.1088/1741-2560/7/1/016011; James et al. 2015). Here, we show that highly successful classification of PTSD and control subjects can be obtained using neural correlations from prewhitened resting-state fMRI data. All but one PTSD (14/15; sensitivity = 93.3 %) and all but one control (20/21; specificity = 95.2 %) subjects were correctly classified using 15 out of 2701 possible correlations between 74 brain areas. In contrast, correlations of the same but non-prewhitened data yielded chance-level classifications. We conclude that, if properly processed, fMRI has the prospect of aiding significantly in PTSD diagnosis. Twenty-five brain areas were most prominently involved in correct subject classification, including areas from all cortical lobes and the left pallidum.",

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Diagnosis of posttraumatic stress disorder (PTSD) based on correlations of prewhitened fMRI data: outcomes and areas involved

Abstract

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Keywords

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