Abstract
Plasma diatrizoate concentrations during computed cranial tomography were measured by UV spectrophotometry in 14 patients. A loading dose of 0.82 mg diatrizoate/kg followed by a steady infusion of 0.01 mg/kg was required to attain and maintain plasma concentrations of approximately 400 mg/100 ml. Lowering the beam energy resulted in a substantial increase in the EMI numbers of diatrizoate and significant improvement in the delineation of contrast containing lesions. A contrast index estimating the volume of a pixel containing diatrizoate was calculated for five diagnosed lesions and this factor appears to be related to vascularity and extravasation.
Original language | English (US) |
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Pages (from-to) | 21-26 |
Number of pages | 6 |
Journal | Investigative Radiology |
Volume | 12 |
Issue number | 1 |
DOIs | |
State | Published - 1977 |
Keywords
- Brain
- CT scan
- Computed cranial tomography
- Diatrizoate
- EMI scan