TY - JOUR
T1 - Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells
AU - Lokensgard, James R.
AU - Gekker, Genya
AU - Hu, Shuxian
AU - Arthur, Andrew F.
AU - Chao, Chun C.
AU - Peterson, Phillip K.
PY - 1997/11
Y1 - 1997/11
N2 - Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macrophages, and this antiviral activity was associated with decreased activation of nuclear factor kappa B.
AB - Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macrophages, and this antiviral activity was associated with decreased activation of nuclear factor kappa B.
UR - http://www.scopus.com/inward/record.url?scp=0030726760&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030726760&partnerID=8YFLogxK
U2 - 10.1128/aac.41.11.2566
DO - 10.1128/aac.41.11.2566
M3 - Article
C2 - 9371370
AN - SCOPUS:0030726760
SN - 0066-4804
VL - 41
SP - 2566
EP - 2569
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 11
ER -
