TY - JOUR
T1 - Dietary and Lifestyle Oxidative Balance Scores and Incident Colorectal Cancer Risk among Older Women; the Iowa Women’s Health Study
AU - Mao, Ziling
AU - Prizment, Anna E.
AU - Lazovich, De Ann
AU - Gibbs, David C.
AU - Bostick, Roberd M.
N1 - Funding Information:
This work was supported by the National Cancer Institute at the National Institutes of Health under Grant R01 CA039742, and the Wilson P. and Anne W. Franklin Foundation.
Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.
PY - 2021
Y1 - 2021
N2 - Background: Basic science literature strongly supports a role of oxidative stress in colorectal cancer (CRC) etiology, but in epidemiologic studies, associations of most individual exposures with CRC have been weak or inconsistent. However, recent epidemiologic evidence suggests that the collective effects of these exposures on oxidative balance and CRC risk may be substantial. Methods: Using food frequency and lifestyle questionnaire data from the prospective Iowa Women’s Health Study (1986-2012), we investigated associations of 11-component dietary and 4-component lifestyle oxidative balance scores (OBS) with incident CRC using multivariable Cox proportional hazards regression. Results: Of the 33,736 cancer-free women aged 55-69 years at baseline, 1,632 developed CRC during follow-up. Among participants in the highest relative to the lowest dietary and lifestyle OBS quintiles (higher anti-oxidant relative to pro-oxidant exposures), the adjusted hazard ratios (HRs) and their 95% confidence intervals (CI) were, respectively, 0.77 (0.63, 0.94) (Ptrend =0.02) and 0.61 (0.52, 0.71) (Ptrend <0.0001). Among those in the highest relative to the lowest joint lifestyle/dietary OBS quintile, the HR was 0.45 (95% CI 0.26, 0.77). Conclusions: Our findings suggest that a predominance of antioxidant over pro-oxidant dietary and lifestyle exposures—separately and especially jointly—may be inversely associated with CRC risk among older women.
AB - Background: Basic science literature strongly supports a role of oxidative stress in colorectal cancer (CRC) etiology, but in epidemiologic studies, associations of most individual exposures with CRC have been weak or inconsistent. However, recent epidemiologic evidence suggests that the collective effects of these exposures on oxidative balance and CRC risk may be substantial. Methods: Using food frequency and lifestyle questionnaire data from the prospective Iowa Women’s Health Study (1986-2012), we investigated associations of 11-component dietary and 4-component lifestyle oxidative balance scores (OBS) with incident CRC using multivariable Cox proportional hazards regression. Results: Of the 33,736 cancer-free women aged 55-69 years at baseline, 1,632 developed CRC during follow-up. Among participants in the highest relative to the lowest dietary and lifestyle OBS quintiles (higher anti-oxidant relative to pro-oxidant exposures), the adjusted hazard ratios (HRs) and their 95% confidence intervals (CI) were, respectively, 0.77 (0.63, 0.94) (Ptrend =0.02) and 0.61 (0.52, 0.71) (Ptrend <0.0001). Among those in the highest relative to the lowest joint lifestyle/dietary OBS quintile, the HR was 0.45 (95% CI 0.26, 0.77). Conclusions: Our findings suggest that a predominance of antioxidant over pro-oxidant dietary and lifestyle exposures—separately and especially jointly—may be inversely associated with CRC risk among older women.
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U2 - 10.1080/01635581.2020.1821904
DO - 10.1080/01635581.2020.1821904
M3 - Article
C2 - 32981353
AN - SCOPUS:85091603478
SN - 0163-5581
VL - 73
SP - 2323
EP - 2335
JO - Nutrition and Cancer
JF - Nutrition and Cancer
IS - 11-12
ER -