TY - JOUR
T1 - Dietary intake of n-3 fatty acids and the risk of acute myocardial infarction
T2 - A case-control study
AU - Fernández-Jarne, Elena
AU - Alegre Garrido, Félix
AU - Alonso Gutiérrez, álvaro
AU - De La Fuente Arrillaga, Carmen
AU - Martínez-González, Miguel ángel
PY - 2002
Y1 - 2002
N2 - Background: There is some dispute about the role of fish and n-3 polyunsaturated fatty acids (n-3 PUFA) consumption on the prevention of coronary heart disease. The aim of this study was to analyze the relationship between n-3 PUFA and fish consumption and the risk of a first acute myocardial infarction (AMI) in a low risk population from Navarre (Spain). Method: A hospital-based case-control study was conducted in Pamplona (Spain). We included 171 patients (81% males, age < 80 years) who were admitted with a first acute myocardial infarction and 171 age-, gender- and hospital-matched controls were selected. A validated semiquantitative food frequency questionnaire was administered and face-to-face interviews were performed. Conditional logistic regression modeling was used to take into account potential confounders. Results: Adjusted odds ratio (OR) and 95% confidence intervals (CI) for the second and third tertile of n-3 PUFA intake were 0.44 (95% Cl, 0.21-0.91) and 0.47 (95% Cl, 0.22-1.00), respectively. Trend test was not statistiscally significant. Adjusted OR and 95% Cl for the second and third tertile of fish consumption were 0.40 (95% Cl, 0.19-0.83) and 0.42 (95% Cl, 0.19-0.93), respectively. Additional adjusting for n-3 PUFA led to a non-significant association between fish consumption and AMI. Conclusions: This study reveals a protective effect of n-3 PUFA and fish consumption against AMI. Our results suggest that a threshold exists in the quantitative dose-response relationship between fish intake and AMI.
AB - Background: There is some dispute about the role of fish and n-3 polyunsaturated fatty acids (n-3 PUFA) consumption on the prevention of coronary heart disease. The aim of this study was to analyze the relationship between n-3 PUFA and fish consumption and the risk of a first acute myocardial infarction (AMI) in a low risk population from Navarre (Spain). Method: A hospital-based case-control study was conducted in Pamplona (Spain). We included 171 patients (81% males, age < 80 years) who were admitted with a first acute myocardial infarction and 171 age-, gender- and hospital-matched controls were selected. A validated semiquantitative food frequency questionnaire was administered and face-to-face interviews were performed. Conditional logistic regression modeling was used to take into account potential confounders. Results: Adjusted odds ratio (OR) and 95% confidence intervals (CI) for the second and third tertile of n-3 PUFA intake were 0.44 (95% Cl, 0.21-0.91) and 0.47 (95% Cl, 0.22-1.00), respectively. Trend test was not statistiscally significant. Adjusted OR and 95% Cl for the second and third tertile of fish consumption were 0.40 (95% Cl, 0.19-0.83) and 0.42 (95% Cl, 0.19-0.93), respectively. Additional adjusting for n-3 PUFA led to a non-significant association between fish consumption and AMI. Conclusions: This study reveals a protective effect of n-3 PUFA and fish consumption against AMI. Our results suggest that a threshold exists in the quantitative dose-response relationship between fish intake and AMI.
KW - Coronary disease
KW - Diet
KW - Epidemiology
KW - Fatty acids
UR - http://www.scopus.com/inward/record.url?scp=0037045618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037045618&partnerID=8YFLogxK
U2 - 10.1016/S0025-7753(02)72306-3
DO - 10.1016/S0025-7753(02)72306-3
M3 - Article
C2 - 11841768
AN - SCOPUS:0037045618
SN - 0025-7753
VL - 118
SP - 121
EP - 125
JO - Medicina Clinica
JF - Medicina Clinica
IS - 4
M1 - 72306
ER -