Direct, Differential Effects of Tamoxifen, 4-Hydroxytamoxifen, and Raloxifene on Cardiac Myocyte Contractility and Calcium Handling

Medicine & Life Sciences

• afimoxifene 89%
• Raloxifene Hydrochloride 82%
• Tamoxifen 64%
• Cardiac Myocytes 56%
• Calcium 41%
• Selective Estrogen Receptor Modulators 6%
• Long QT Syndrome 6%
• Gene Knockout Techniques 5%
• Multiple Drug Resistance 4%
• Cardiomyopathies 4%
• Estrogen Receptors 4%
• Glioma 4%
• Muscle Cells 4%
• Pharmaceutical Preparations 3%
• Genes 3%
• Therapeutics 3%
• Heart 3%
• Neoplasms 3%
• Breast Neoplasms 2%

Agriculture & Biology

• tamoxifen 83%
• cardiomyocytes 73%
• calcium 38%
• estrogen receptors 10%
• dosage 7%
• neoplasms 7%
• cardiomyopathy 6%
• drugs 6%
• glioma 6%
• acute effects 6%
• multiple drug resistance 5%
• mice 5%
• breast neoplasms 5%
• gene targeting 4%
• myocytes 4%
• adverse effects 3%
• therapeutics 3%
• heart 3%
• genes 3%
• metabolites 3%
• rats 2%
• tissues 2%
• cells 1%

Chemical Compounds

• Raloxifene 100%
• Tamoxifen 82%
• Calcium(0) 46%
• Selective Estrogen Receptor Modulator 9%
• Dose 9%
• Drug 6%
• Metabolite 4%