Discrepancies in Tuberculin Skin Test Results with Two Commercial Products in a Population of Intravenous Drug Users

Alan R. Lifson; John K. Watters; Suzanne Thompson; Charles M. Crane; Francie Wise; Alan R. Lifson; John K. Watters; Suzanne Thompson; Charles M. Crane; Francie Wise

doi:10.1093/infdis/168.4.1048

Discrepancies in Tuberculin Skin Test Results with Two Commercial Products in a Population of Intravenous Drug Users

Alan R. Lifson, John K. Watters, Suzanne Thompson, Charles M. Crane, Francie Wise, Alan R. Lifson, John K. Watters, Suzanne Thompson, Charles M. Crane, Francie Wise

Epidemiology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Screening for tuberculosis (using the Mantoux test) and human immunodeficiency virus (HIV) was conducted among intravenous drug users (IVDUs) recruited from a San Francisco Bay Area neighborhood. Of 178 IVDUs skin-tested with one commercial purified protein derivative (PPD) preparation, a reaction of ⩾5 mm ofinduration occurred in 62 (470/0) of 133 HIV-negative and 13 (29%) of 45 HIV-positive IVDUs (P =.037). Forty-two IVDUs with an initial PPD reaction ⩾5 mm were retested with a second commercial preparation; 11 (26%) had no reaction (0 mm) on retesting. These 11 were 5 (56%) of9 HIV-positive and 6 (18%) of33 HIV-negative persons (P =.038). These discrepancies may be unique to specific lots of product or may reflect more general differences. A degree of caution in evaluating unexpected tuberculin skin test results may be indicated. Response to different tuberculin products by HIV status should be further evaluated.

Original language	English (US)
Pages (from-to)	1048-1051
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	168
Issue number	4
DOIs	https://doi.org/10.1093/infdis/168.4.1048
State	Published - Oct 1993

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title = "Discrepancies in Tuberculin Skin Test Results with Two Commercial Products in a Population of Intravenous Drug Users",

abstract = "Screening for tuberculosis (using the Mantoux test) and human immunodeficiency virus (HIV) was conducted among intravenous drug users (IVDUs) recruited from a San Francisco Bay Area neighborhood. Of 178 IVDUs skin-tested with one commercial purified protein derivative (PPD) preparation, a reaction of ⩾5 mm ofinduration occurred in 62 (470/0) of 133 HIV-negative and 13 (29%) of 45 HIV-positive IVDUs (P =.037). Forty-two IVDUs with an initial PPD reaction ⩾5 mm were retested with a second commercial preparation; 11 (26%) had no reaction (0 mm) on retesting. These 11 were 5 (56%) of9 HIV-positive and 6 (18%) of33 HIV-negative persons (P =.038). These discrepancies may be unique to specific lots of product or may reflect more general differences. A degree of caution in evaluating unexpected tuberculin skin test results may be indicated. Response to different tuberculin products by HIV status should be further evaluated.",

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AU - Thompson, Suzanne

AU - Crane, Charles M.

AU - Wise, Francie

AU - Lifson, Alan R.

AU - Watters, John K.

AU - Thompson, Suzanne

AU - Crane, Charles M.

AU - Wise, Francie

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Discrepancies in Tuberculin Skin Test Results with Two Commercial Products in a Population of Intravenous Drug Users

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