TY - JOUR
T1 - Dissemination of Circulating Tumor Cells in Breast and Prostate Cancer
T2 - Implications for Early Detection
AU - Bae, Song Yi
AU - Kamalanathan, Kaylee Judith
AU - Galeano-Garces, Catalina
AU - Konety, Badrinath R
AU - Antonarakis, Emmanuel S.
AU - Parthasarathy, Jayant
AU - Hong, Jiarong
AU - Drake, Justin M.
N1 - Publisher Copyright:
© 2024 Endocrine Society. All rights reserved.
PY - 2024/4/1
Y1 - 2024/4/1
N2 - Burgeoning evidence suggests that circulating tumor cells (CTCs) may disseminate into blood vessels at an early stage, seeding metastases in various cancers such as breast and prostate cancer. Simultaneously, the early-stage CTCs that settle in metastatic sites [termed disseminated tumor cells (DTCs)] can enter dormancy, marking a potential source of late recurrence and therapy resistance. Thus, the presence of these early CTCs poses risks to patients but also holds potential benefits for early detection and treatment and opportunities for possibly curative interventions. This review delves into the role of early DTCs in driving latent metastasis within breast and prostate cancer, emphasizing the importance of early CTC detection in these diseases. We further explore the correlation between early CTC detection and poor prognoses, which contribute significantly to increased cancer mortality. Consequently, the detection of CTCs at an early stage emerges as a critical imperative for enhancing clinical diagnostics and allowing for early interventions.
AB - Burgeoning evidence suggests that circulating tumor cells (CTCs) may disseminate into blood vessels at an early stage, seeding metastases in various cancers such as breast and prostate cancer. Simultaneously, the early-stage CTCs that settle in metastatic sites [termed disseminated tumor cells (DTCs)] can enter dormancy, marking a potential source of late recurrence and therapy resistance. Thus, the presence of these early CTCs poses risks to patients but also holds potential benefits for early detection and treatment and opportunities for possibly curative interventions. This review delves into the role of early DTCs in driving latent metastasis within breast and prostate cancer, emphasizing the importance of early CTC detection in these diseases. We further explore the correlation between early CTC detection and poor prognoses, which contribute significantly to increased cancer mortality. Consequently, the detection of CTCs at an early stage emerges as a critical imperative for enhancing clinical diagnostics and allowing for early interventions.
KW - breast cancer
KW - circulating tumor cells
KW - early detection
KW - prostate cancer
KW - tumor dormancy
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UR - http://www.scopus.com/inward/citedby.url?scp=85186373990&partnerID=8YFLogxK
U2 - 10.1210/endocr/bqae022
DO - 10.1210/endocr/bqae022
M3 - Review article
C2 - 38366552
AN - SCOPUS:85186373990
SN - 0013-7227
VL - 165
JO - Endocrinology
JF - Endocrinology
IS - 4
M1 - bqae022
ER -