DNA ligase and PCNA: Double-ring down to seal a break in DNA

Hideki Aihara

doi:10.1016/j.str.2022.02.008

DNA ligase and PCNA: Double-ring down to seal a break in DNA

Hideki Aihara

Chemical and Structural Biology (BMBB)

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The structures provide snapshots of ligation intermediates, which reveal a dynamic nature of the complex and explain how PCNA stimulates the DNA ligase activity.

Original language	English (US)
Pages (from-to)	324-326
Number of pages	3
Journal	Structure
Volume	30
Issue number	3
DOIs	https://doi.org/10.1016/j.str.2022.02.008
State	Published - Mar 3 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Ltd

Access

10.1016/j.str.2022.02.008

OpenUrl availability

Full text

Cite this

@article{eb642fccac514dd59651b4ae53ca4d10,

title = "DNA ligase and PCNA: Double-ring down to seal a break in DNA",

abstract = "In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The structures provide snapshots of ligation intermediates, which reveal a dynamic nature of the complex and explain how PCNA stimulates the DNA ligase activity.",

author = "Hideki Aihara",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = mar,

day = "3",

doi = "10.1016/j.str.2022.02.008",

language = "English (US)",

volume = "30",

pages = "324--326",

journal = "Structure",

issn = "0969-2126",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - DNA ligase and PCNA

T2 - Double-ring down to seal a break in DNA

AU - Aihara, Hideki

PY - 2022/3/3

Y1 - 2022/3/3

N2 - In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The structures provide snapshots of ligation intermediates, which reveal a dynamic nature of the complex and explain how PCNA stimulates the DNA ligase activity.

AB - In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The structures provide snapshots of ligation intermediates, which reveal a dynamic nature of the complex and explain how PCNA stimulates the DNA ligase activity.

UR - http://www.scopus.com/inward/record.url?scp=85125240186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85125240186&partnerID=8YFLogxK

U2 - 10.1016/j.str.2022.02.008

DO - 10.1016/j.str.2022.02.008

M3 - Comment/debate

C2 - 35245433

AN - SCOPUS:85125240186

SN - 0969-2126

VL - 30

SP - 324

EP - 326

JO - Structure

JF - Structure

IS - 3

ER -

DNA ligase and PCNA: Double-ring down to seal a break in DNA

Abstract

Bibliographical note

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this