DNA methylation-derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival

Bo Yang; Melissa Eliot; Michael D. McClean; Tim Waterboer; Michael Pawlita; Rondi Butler; Heather H. Nelson; Scott M. Langevin; Brock C. Christensen; Karl T. Kelsey

doi:10.1002/hed.26981

DNA methylation-derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival

Bo Yang, Melissa Eliot, Michael D. McClean, Tim Waterboer, Michael Pawlita, Rondi Butler, Heather H. Nelson, Scott M. Langevin, Brock C. Christensen, Karl T. Kelsey

Epidemiology

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2 Scopus citations

Abstract

Background: Head and neck squamous cell carcinomas are associated with systemic inflammation (SI). We evaluated whether DNA methylation-derived SI (mdSI) indices are associated with oropharyngeal cancer risk and survival. Methods: Ninety-four oropharyngeal squamous cell carcinoma (OPSCC) cases and 57 controls with DNA methylation data were included. Logistic regression analysis and survival analysis were performed to test the association of mdSI indices with OPSCC risk and survival. Results: Higher methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) was associated with increased risk of OPSCC (OR = 1.21, 95%CI: 1.11–1.40) while no association was found with methylation-derived lymphocyte-to-monocyte ratio (mdLMR). For 5-year overall survival, higher mdLMR was significantly associated with decreased risk of death (HR = 0.25, 95%CI: 0.10–0.64) while the converse was observed for mdNLR (HR = 2.48, 95%CI: 1.04–5.92). Conclusion: We observed an association between mdSI indices and OPSCC risk and 5-year overall survival. It is possible to use mdLMR as an independent prognostic factor for OPSCC.

Original language	English (US)
Pages (from-to)	904-913
Number of pages	10
Journal	Head and Neck
Volume	44
Issue number	4
DOIs	https://doi.org/10.1002/hed.26981
State	Published - Apr 2022

Bibliographical note

Publisher Copyright:
© 2022 Wiley Periodicals LLC.

Keywords

DNA methylation
head and neck cancer
lymphocyte-to-monocyte ratio
neutrophil-to-lymphocyte ratio
oropharyngeal cancer

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "DNA methylation-derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival",

abstract = "Background: Head and neck squamous cell carcinomas are associated with systemic inflammation (SI). We evaluated whether DNA methylation-derived SI (mdSI) indices are associated with oropharyngeal cancer risk and survival. Methods: Ninety-four oropharyngeal squamous cell carcinoma (OPSCC) cases and 57 controls with DNA methylation data were included. Logistic regression analysis and survival analysis were performed to test the association of mdSI indices with OPSCC risk and survival. Results: Higher methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) was associated with increased risk of OPSCC (OR = 1.21, 95%CI: 1.11–1.40) while no association was found with methylation-derived lymphocyte-to-monocyte ratio (mdLMR). For 5-year overall survival, higher mdLMR was significantly associated with decreased risk of death (HR = 0.25, 95%CI: 0.10–0.64) while the converse was observed for mdNLR (HR = 2.48, 95%CI: 1.04–5.92). Conclusion: We observed an association between mdSI indices and OPSCC risk and 5-year overall survival. It is possible to use mdLMR as an independent prognostic factor for OPSCC.",

keywords = "DNA methylation, head and neck cancer, lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, oropharyngeal cancer",

author = "Bo Yang and Melissa Eliot and McClean, {Michael D.} and Tim Waterboer and Michael Pawlita and Rondi Butler and Nelson, {Heather H.} and Langevin, {Scott M.} and Christensen, {Brock C.} and Kelsey, {Karl T.}",

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year = "2022",

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doi = "10.1002/hed.26981",

language = "English (US)",

volume = "44",

pages = "904--913",

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T1 - DNA methylation-derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival

AU - Yang, Bo

AU - Eliot, Melissa

AU - McClean, Michael D.

AU - Waterboer, Tim

AU - Pawlita, Michael

AU - Butler, Rondi

AU - Nelson, Heather H.

AU - Langevin, Scott M.

AU - Christensen, Brock C.

AU - Kelsey, Karl T.

PY - 2022/4

Y1 - 2022/4

N2 - Background: Head and neck squamous cell carcinomas are associated with systemic inflammation (SI). We evaluated whether DNA methylation-derived SI (mdSI) indices are associated with oropharyngeal cancer risk and survival. Methods: Ninety-four oropharyngeal squamous cell carcinoma (OPSCC) cases and 57 controls with DNA methylation data were included. Logistic regression analysis and survival analysis were performed to test the association of mdSI indices with OPSCC risk and survival. Results: Higher methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) was associated with increased risk of OPSCC (OR = 1.21, 95%CI: 1.11–1.40) while no association was found with methylation-derived lymphocyte-to-monocyte ratio (mdLMR). For 5-year overall survival, higher mdLMR was significantly associated with decreased risk of death (HR = 0.25, 95%CI: 0.10–0.64) while the converse was observed for mdNLR (HR = 2.48, 95%CI: 1.04–5.92). Conclusion: We observed an association between mdSI indices and OPSCC risk and 5-year overall survival. It is possible to use mdLMR as an independent prognostic factor for OPSCC.

AB - Background: Head and neck squamous cell carcinomas are associated with systemic inflammation (SI). We evaluated whether DNA methylation-derived SI (mdSI) indices are associated with oropharyngeal cancer risk and survival. Methods: Ninety-four oropharyngeal squamous cell carcinoma (OPSCC) cases and 57 controls with DNA methylation data were included. Logistic regression analysis and survival analysis were performed to test the association of mdSI indices with OPSCC risk and survival. Results: Higher methylation-derived neutrophil-to-lymphocyte ratio (mdNLR) was associated with increased risk of OPSCC (OR = 1.21, 95%CI: 1.11–1.40) while no association was found with methylation-derived lymphocyte-to-monocyte ratio (mdLMR). For 5-year overall survival, higher mdLMR was significantly associated with decreased risk of death (HR = 0.25, 95%CI: 0.10–0.64) while the converse was observed for mdNLR (HR = 2.48, 95%CI: 1.04–5.92). Conclusion: We observed an association between mdSI indices and OPSCC risk and 5-year overall survival. It is possible to use mdLMR as an independent prognostic factor for OPSCC.

KW - DNA methylation

KW - head and neck cancer

KW - lymphocyte-to-monocyte ratio

KW - neutrophil-to-lymphocyte ratio

KW - oropharyngeal cancer

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DNA methylation-derived systemic inflammation indices and their association with oropharyngeal cancer risk and survival

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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