Do stars govern our actions? Astrocyte involvement in rodent behavior

João Filipe Oliveira; Vanessa Morais Sardinha; Sónia Guerra-Gomes; Alfonso Araque; Nuno Sousa

doi:10.1016/j.tins.2015.07.006

Do stars govern our actions? Astrocyte involvement in rodent behavior

João Filipe Oliveira, Vanessa Morais Sardinha, Sónia Guerra-Gomes, Alfonso Araque, Nuno Sousa

Neuroscience

Research output: Contribution to journal › Review article › peer-review

129 Scopus citations

Abstract

Astrocytes have emerged as important partners of neurons in information processing. Important progress has been made in the past two decades in understanding the role of astrocytes in the generation of neuron-astrocyte network outputs resulting in behavior. We review evidence for astrocyte involvement across four different behavioral domains: cognition, emotion, motor, and sensory processing. Accumulating evidence from animal models has provided a wealth of data that largely supports a direct involvement of astrocytes on diverse aspects of behavior. The development of tools for selectively controlling the temporal and spatial properties of astrocyte activity will help to consolidate our knowledge of the mechanisms underlying this involvement.

Original language	English (US)
Pages (from-to)	535-549
Number of pages	15
Journal	Trends in Neurosciences
Volume	38
Issue number	9
DOIs	https://doi.org/10.1016/j.tins.2015.07.006
State	Published - Sep 1 2015

Bibliographical note

Funding Information:
The authors acknowledge funding from the Marie Curie Fellowship FP7-PEOPLE-2010-IEF 273936 and BIAL Foundation Grant 61/2010 to J.F.O.; Foundation for Science and Technology (FCT) project grant (PTDC/SAU-NSC/118194/2010) to J.F.O., V.M.S., and S.G.G.; and fellowships (SFRH/BD/89714/2012 to V.M.S., SFRH/BPD/97281/2013 to J.F.O. and SFRH/BD/101298/2014 to S.G.G.); Human Frontier Science Program (Research Grant RGP0036/2014) to A.A.; FEDER funds through the Operational Program for Competitiveness Factors (COMPETE), and ‘ON2 Programa Operacional Regional do Norte (ON.2 O Novo Norte)’ QREN/FEDER to N.S.

Publisher Copyright:
© 2015 Elsevier Ltd.

Keywords

Astrocyte
Behavior
Cognition
Emotion
Motor
Sensorial

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abstract = "Astrocytes have emerged as important partners of neurons in information processing. Important progress has been made in the past two decades in understanding the role of astrocytes in the generation of neuron-astrocyte network outputs resulting in behavior. We review evidence for astrocyte involvement across four different behavioral domains: cognition, emotion, motor, and sensory processing. Accumulating evidence from animal models has provided a wealth of data that largely supports a direct involvement of astrocytes on diverse aspects of behavior. The development of tools for selectively controlling the temporal and spatial properties of astrocyte activity will help to consolidate our knowledge of the mechanisms underlying this involvement.",

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Do stars govern our actions? Astrocyte involvement in rodent behavior

Abstract

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Keywords

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