TY - JOUR
T1 - Double volume exchange transfusion for ABO incompatible liver transplantation in paediatric patients
T2 - Intraoperative and preoperative approach
AU - Beebe, David S.
AU - Peña, Annie
AU - Payne, William D
AU - Belani, Kumar G.
PY - 1998
Y1 - 1998
N2 - Double volume blood exchange transfusions (DBVET) were used to reduce the serum antibody levels in six paediatric patients receiving ABO incompatible hepatic allografts. In four patients, the exchange transfusions took place on the ward prior to surgery. In three of these four patients who had titres measured, the anti-A IgM titres fell from 1024 to 64, 64 to 8, and 128 to 16, respectively. The anti-A IgG titres fell from 32 to 16 and 512 to 64 in two patients, but rose from 16 to 32 in the third. In two patients DBVET were performed intraoperatively using a rapid infusion device. The IgM titres fell from 256 to 32 and 64 to 1, respectively, and the IgG titres fell from 16 to 4 and 2 to 0. Intraoperative DBVET can acutely and effectively reduce blood group antibodies. Intraoperative DBVET may reduce graft ischaemia time and allow red blood cell salvage.
AB - Double volume blood exchange transfusions (DBVET) were used to reduce the serum antibody levels in six paediatric patients receiving ABO incompatible hepatic allografts. In four patients, the exchange transfusions took place on the ward prior to surgery. In three of these four patients who had titres measured, the anti-A IgM titres fell from 1024 to 64, 64 to 8, and 128 to 16, respectively. The anti-A IgG titres fell from 32 to 16 and 512 to 64 in two patients, but rose from 16 to 32 in the third. In two patients DBVET were performed intraoperatively using a rapid infusion device. The IgM titres fell from 256 to 32 and 64 to 1, respectively, and the IgG titres fell from 16 to 4 and 2 to 0. Intraoperative DBVET can acutely and effectively reduce blood group antibodies. Intraoperative DBVET may reduce graft ischaemia time and allow red blood cell salvage.
KW - Blood group incompatibility
KW - Exchange transfusion
KW - Liver transplantation
KW - Rapid infusion device
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U2 - 10.1046/j.1460-9592.1998.00240.x
DO - 10.1046/j.1460-9592.1998.00240.x
M3 - Article
C2 - 9608964
AN - SCOPUS:0031799698
SN - 1155-5645
VL - 8
SP - 205
EP - 210
JO - Paediatric anaesthesia
JF - Paediatric anaesthesia
IS - 3
ER -