Drosophila heparan sulfate 6-o-endosulfatase sulf1 facilitates wingless (Wg) protein degradation

Adam Kleinschmit; Masahiko Takemura; Katsufumi Dejima; Pui Yee Choi; Hiroshi Nakato

doi:10.1074/jbc.M112.447029

Drosophila heparan sulfate 6-o-endosulfatase sulf1 facilitates wingless (Wg) protein degradation

Adam Kleinschmit, Masahiko Takemura, Katsufumi Dejima, Pui Yee Choi, Hiroshi Nakato

Genetics, Cell Biology and Development (CBS)

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Background: Heparan sulfate 6-O-endosulfatases (Sulfs) have opposite effects on Wnt signaling in vertebrates and Drosophila systems. Results: Sulf1 expression in Drosophila leads to Wingless degradation. Conclusion: Vertebrate and Drosophila Sulfs have an intrinsically similar enzymatic activity, but exert different effects on Wnt/Wg signaling in a context-dependent manner. Significance: This finding contributes to the understanding of extracellular regulation of Wnt/Wg signaling.

Original language	English (US)
Pages (from-to)	5081-5089
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M112.447029
State	Published - Feb 15 2013

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abstract = "Background: Heparan sulfate 6-O-endosulfatases (Sulfs) have opposite effects on Wnt signaling in vertebrates and Drosophila systems. Results: Sulf1 expression in Drosophila leads to Wingless degradation. Conclusion: Vertebrate and Drosophila Sulfs have an intrinsically similar enzymatic activity, but exert different effects on Wnt/Wg signaling in a context-dependent manner. Significance: This finding contributes to the understanding of extracellular regulation of Wnt/Wg signaling.",

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AU - Kleinschmit, Adam

AU - Takemura, Masahiko

AU - Dejima, Katsufumi

AU - Choi, Pui Yee

AU - Nakato, Hiroshi

PY - 2013/2/15

Y1 - 2013/2/15

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AB - Background: Heparan sulfate 6-O-endosulfatases (Sulfs) have opposite effects on Wnt signaling in vertebrates and Drosophila systems. Results: Sulf1 expression in Drosophila leads to Wingless degradation. Conclusion: Vertebrate and Drosophila Sulfs have an intrinsically similar enzymatic activity, but exert different effects on Wnt/Wg signaling in a context-dependent manner. Significance: This finding contributes to the understanding of extracellular regulation of Wnt/Wg signaling.

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Drosophila heparan sulfate 6-o-endosulfatase sulf1 facilitates wingless (Wg) protein degradation

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