Dynamics of Microtubule Self-Assembly

B. T. Castle; David J Odde

doi:10.1016/B978-0-12-821618-7.40005-2

Dynamics of Microtubule Self-Assembly

B. T. Castle, David J Odde

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Microtubules are linear intracellular polymers that self-assemble from subunits of αβ-tubulin heterodimers, and serve as essential mediators of cellular processes including cell division, migration, as well as intracellular transport. Each of these functions is dependent on the microtubule structure and self-assembly dynamics. Here we discuss the dynamics of microtubule structure and subunit addition and loss in the process of microtubule self-assembly, highlighting how these nanometer/molecular-scale dynamics manifest themselves at the micrometer/cellular-scale.

Original language	English (US)
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Volume 1-6, Second Edition
Publisher	Elsevier
Pages	201-210
Number of pages	10
Volume	6
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.40005-2
State	Published - Jan 1 2022

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© 2023 Elsevier Inc. All rights reserved.

Keywords

Catastrophe
Dynamic instability
GTP cap
Hydrolysis
Kinetic stabilization
Kinetics
MAPs
Microtubule
Rescue
Self-assembly
Thermodynamics

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KW - Catastrophe

KW - Dynamic instability

KW - GTP cap

KW - Hydrolysis

KW - Kinetic stabilization

KW - Kinetics

KW - MAPs

KW - Microtubule

KW - Rescue

KW - Self-assembly

KW - Thermodynamics

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VL - 6

SP - 201

EP - 210

BT - Encyclopedia of Cell Biology

PB - Elsevier

ER -

Dynamics of Microtubule Self-Assembly

Abstract

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Keywords

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