Dysregulation of astrocyte–neuronal communication in Alzheimer’s disease

Carmen Nanclares; Andres Mateo Baraibar; Alfonso Araque; Paulo Kofuji

doi:10.3390/ijms22157887

Dysregulation of astrocyte–neuronal communication in Alzheimer’s disease

Carmen Nanclares, Andres Mateo Baraibar, Alfonso Araque, Paulo Kofuji

Neuroscience

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

Recent studies implicate astrocytes in Alzheimer’s disease (AD); however, their role in pathogenesis is poorly understood. Astrocytes have well-established functions in supportive functions such as extracellular ionic homeostasis, structural support, and neurovascular coupling. However, emerging research on astrocytic function in the healthy brain also indicates their role in regulating synaptic plasticity and neuronal excitability via the release of neuroactive substances named gliotransmitters. Here, we review how this “active” role of astrocytes at synapses could contribute to synaptic and neuronal network dysfunction and cognitive impairment in AD.

Original language	English (US)
Article number	7887
Journal	International journal of molecular sciences
Volume	22
Issue number	15
DOIs	https://doi.org/10.3390/ijms22157887
State	Published - Aug 1 2021

Bibliographical note

Funding Information:
This work was supported by the National Institutes of Health-NINDS (R01NS097312), National Institutes of Health-NIDA (R01DA048822), National Institutes of Health-NIMH (R01MH119355), and Postdoctoral Research Fellowship from the Basque Government (POS_2019_0041).The authors would like to thank Dana Deters for expert laboratory assistance. view Board Statement: Not applicable. Figures created in Biorender, https://biorender.com, 9 June 2021.

Funding Information:
editedandfinalizetdionthael ImnsatintutsecsroifpHt.eAalltlha-NuItDhoAr(sRh0a1vDeA r0e4a8d82a2n),dNatgioreneadlIntostitthuet epsuofbHlisehaletdh-NveIMrsHion(Ro01f MH119355), the manuscript. and Postdoctoral Research Fellowship from the Basque Government (POS_2019_0041).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Alzheimer’s disease
Amyloid plaques
Calcium
Glia
Gliotransmission

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abstract = "Recent studies implicate astrocytes in Alzheimer{\textquoteright}s disease (AD); however, their role in pathogenesis is poorly understood. Astrocytes have well-established functions in supportive functions such as extracellular ionic homeostasis, structural support, and neurovascular coupling. However, emerging research on astrocytic function in the healthy brain also indicates their role in regulating synaptic plasticity and neuronal excitability via the release of neuroactive substances named gliotransmitters. Here, we review how this “active” role of astrocytes at synapses could contribute to synaptic and neuronal network dysfunction and cognitive impairment in AD.",

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note = "Funding Information: This work was supported by the National Institutes of Health-NINDS (R01NS097312), National Institutes of Health-NIDA (R01DA048822), National Institutes of Health-NIMH (R01MH119355), and Postdoctoral Research Fellowship from the Basque Government (POS_2019_0041).The authors would like to thank Dana Deters for expert laboratory assistance. view Board Statement: Not applicable. Figures created in Biorender, https://biorender.com, 9 June 2021. Funding Information: editedandfinalizetdionthael ImnsatintutsecsroifpHt.eAalltlha-NuItDhoAr(sRh0a1vDeA r0e4a8d82a2n),dNatgioreneadlIntostitthuet epsuofbHlisehaletdh-NveIMrsHion(Ro01f MH119355), the manuscript. and Postdoctoral Research Fellowship from the Basque Government (POS_2019_0041). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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Dysregulation of astrocyte–neuronal communication in Alzheimer’s disease

Abstract

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Keywords

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