Effect of topical diphenhydramine on the laryngeal chemoreflex

Holly C Boyer; Daniel H. Downs; George Goding; Kerri J. Pernell

doi:10.1001/archotol.1996.01890220078013

Effect of topical diphenhydramine on the laryngeal chemoreflex

Holly C Boyer, Daniel H. Downs, George Goding, Kerri J. Pernell

Otolaryngology

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: To study diphenhydramine nebulization as a clinically applicable method for blunting laryngeal chemoreflex (LCR)-associated apnea. Intervention: Fourteen piglets aged 15 to 18 days were studied. In 7 piglets, diphenhydramine hydrochloride (5.0 mg/kg) was nebulized onto the laryngeal mucosa after a baseline response was obtained. Results: After a 10-minute waiting period, the mean±SD LCR-induced apnea duration decreased from 29±13 seconds in the control animals to 15±5 seconds in the treated group (P=.02, 1-factor analysis of variance). After 1 hour, no treatment effect was seen. Conclusions: Nebulization of diphenhydramine can effectively reduce LCR- induced apnea for a short time. Nebulization of longer-acting agents may provide an effective prophylaxis of LCR-induced apnea.

Original language	English (US)
Pages (from-to)	1112-1116
Number of pages	5
Journal	Archives of Otolaryngology - Head and Neck Surgery
Volume	122
Issue number	10
DOIs	https://doi.org/10.1001/archotol.1996.01890220078013
State	Published - Oct 1996

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title = "Effect of topical diphenhydramine on the laryngeal chemoreflex",

abstract = "Objective: To study diphenhydramine nebulization as a clinically applicable method for blunting laryngeal chemoreflex (LCR)-associated apnea. Intervention: Fourteen piglets aged 15 to 18 days were studied. In 7 piglets, diphenhydramine hydrochloride (5.0 mg/kg) was nebulized onto the laryngeal mucosa after a baseline response was obtained. Results: After a 10-minute waiting period, the mean±SD LCR-induced apnea duration decreased from 29±13 seconds in the control animals to 15±5 seconds in the treated group (P=.02, 1-factor analysis of variance). After 1 hour, no treatment effect was seen. Conclusions: Nebulization of diphenhydramine can effectively reduce LCR- induced apnea for a short time. Nebulization of longer-acting agents may provide an effective prophylaxis of LCR-induced apnea.",

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AU - Downs, Daniel H.

AU - Goding, George

AU - Pernell, Kerri J.

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Effect of topical diphenhydramine on the laryngeal chemoreflex

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