Effect of Various Modifiers on Selectivity in Packed-Column Subcritical and Supercritical Fluid Chromatography

Gary O. Cantrell; Rodger W. Stringham; John A. Blackwell; Jeff D. Weckwerth; Peter W. Carr

doi:10.1021/ac960488f

Effect of Various Modifiers on Selectivity in Packed-Column Subcritical and Supercritical Fluid Chromatography

Gary O. Cantrell, Rodger W. Stringham, John A. Blackwell, Jeff D. Weckwerth, Peter W. Carr

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

A number of common mobile phase modifiers were characterized by chromatographing monofunctional probe solutes on a cyano-bonded stationary phase under subcritical and supercritical conditions. Solvatochromic analysis techniques were used to characterize the relative selectivity, efficiency, and eluotropic strengths of the various modified mobile phases. Analysis of the combined results suggests that modifier choice may be made in a rational manner to either enhance or mask a particular type of molecular interaction. This control is necessary for challenging applications such as chiral separations. The relative effects of each modifier property change depending on whether the Chromatographic system is subcritical or supercritical, thus making knowledge of the phase equilibria associated with the mobile phase essential.

Original language	English (US)
Pages (from-to)	3645-3650
Number of pages	6
Journal	Analytical Chemistry
Volume	68
Issue number	20
DOIs	https://doi.org/10.1021/ac960488f
State	Published - Oct 15 1996

Access

10.1021/ac960488f

OpenUrl availability

Full text

Cite this

@article{8918269d3fdd4c7fab54e09d861fdf2c,

title = "Effect of Various Modifiers on Selectivity in Packed-Column Subcritical and Supercritical Fluid Chromatography",

abstract = "A number of common mobile phase modifiers were characterized by chromatographing monofunctional probe solutes on a cyano-bonded stationary phase under subcritical and supercritical conditions. Solvatochromic analysis techniques were used to characterize the relative selectivity, efficiency, and eluotropic strengths of the various modified mobile phases. Analysis of the combined results suggests that modifier choice may be made in a rational manner to either enhance or mask a particular type of molecular interaction. This control is necessary for challenging applications such as chiral separations. The relative effects of each modifier property change depending on whether the Chromatographic system is subcritical or supercritical, thus making knowledge of the phase equilibria associated with the mobile phase essential.",

author = "Cantrell, {Gary O.} and Stringham, {Rodger W.} and Blackwell, {John A.} and Weckwerth, {Jeff D.} and Carr, {Peter W.}",

year = "1996",

month = oct,

day = "15",

doi = "10.1021/ac960488f",

language = "English (US)",

volume = "68",

pages = "3645--3650",

journal = "Analytical Chemistry",

issn = "0003-2700",

number = "20",

}

TY - JOUR

T1 - Effect of Various Modifiers on Selectivity in Packed-Column Subcritical and Supercritical Fluid Chromatography

AU - Cantrell, Gary O.

AU - Stringham, Rodger W.

AU - Blackwell, John A.

AU - Weckwerth, Jeff D.

AU - Carr, Peter W.

PY - 1996/10/15

Y1 - 1996/10/15

N2 - A number of common mobile phase modifiers were characterized by chromatographing monofunctional probe solutes on a cyano-bonded stationary phase under subcritical and supercritical conditions. Solvatochromic analysis techniques were used to characterize the relative selectivity, efficiency, and eluotropic strengths of the various modified mobile phases. Analysis of the combined results suggests that modifier choice may be made in a rational manner to either enhance or mask a particular type of molecular interaction. This control is necessary for challenging applications such as chiral separations. The relative effects of each modifier property change depending on whether the Chromatographic system is subcritical or supercritical, thus making knowledge of the phase equilibria associated with the mobile phase essential.

AB - A number of common mobile phase modifiers were characterized by chromatographing monofunctional probe solutes on a cyano-bonded stationary phase under subcritical and supercritical conditions. Solvatochromic analysis techniques were used to characterize the relative selectivity, efficiency, and eluotropic strengths of the various modified mobile phases. Analysis of the combined results suggests that modifier choice may be made in a rational manner to either enhance or mask a particular type of molecular interaction. This control is necessary for challenging applications such as chiral separations. The relative effects of each modifier property change depending on whether the Chromatographic system is subcritical or supercritical, thus making knowledge of the phase equilibria associated with the mobile phase essential.

UR - http://www.scopus.com/inward/record.url?scp=0030260026&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030260026&partnerID=8YFLogxK

U2 - 10.1021/ac960488f

DO - 10.1021/ac960488f

M3 - Article

AN - SCOPUS:0030260026

SN - 0003-2700

VL - 68

SP - 3645

EP - 3650

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 20

ER -

Effect of Various Modifiers on Selectivity in Packed-Column Subcritical and Supercritical Fluid Chromatography

Abstract

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this