Effects of pulsatile perfusion on the immunogenicity of renal allografts

William D. Payne; Lester D. Michels; Luis H. Toledo-Pereyra; Richard L. Simmons; John S. Najarian

doi:10.1016/0022-4804(77)90161-5

Effects of pulsatile perfusion on the immunogenicity of renal allografts

William D. Payne, Lester D. Michels, Luis H. Toledo-Pereyra, Richard L. Simmons, John S. Najarian

Surgery

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Abstract

The results in 190 consecutive perfused cadaver renal transplants failed to show a detrimental effect of long-term perfusion. In a controlled study in mongrel dogs, those receiving transplants preserved by pulsatile perfusion for 24 or 48 hr had equal or better survival than those receiving grafts preserved by cold storage or unpreserved grafts. In addition, kidneys preserved for 24 hr by perfusion showed functional abnormalities similar to those preserved as long by cold storage and those transplanted as fresh grafts. It can be concluded that pulsatile perfusion as a means of preservation does not adversely affect long-term function and does not increase the effective immunogenicity of renal allografts.

Original language	English (US)
Pages (from-to)	380-384
Number of pages	5
Journal	Journal of Surgical Research
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/0022-4804(77)90161-5
State	Published - Apr 1977

Bibliographical note

Funding Information:
I Supported by USPHS Grants AM 13083 and Al 12754. W.D.P. is supported by NIH Fellowship 5 F32 Al 05281-02. Address reprint requests to Dr. Payne, Box 304, Mayo Memorial Building, 420 Delaware Street S.E., University of Minnesota Hospitals, Minneapolis, Minn. 55455.

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title = "Effects of pulsatile perfusion on the immunogenicity of renal allografts",

abstract = "The results in 190 consecutive perfused cadaver renal transplants failed to show a detrimental effect of long-term perfusion. In a controlled study in mongrel dogs, those receiving transplants preserved by pulsatile perfusion for 24 or 48 hr had equal or better survival than those receiving grafts preserved by cold storage or unpreserved grafts. In addition, kidneys preserved for 24 hr by perfusion showed functional abnormalities similar to those preserved as long by cold storage and those transplanted as fresh grafts. It can be concluded that pulsatile perfusion as a means of preservation does not adversely affect long-term function and does not increase the effective immunogenicity of renal allografts.",

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note = "Funding Information: I Supported by USPHS Grants AM 13083 and Al 12754. W.D.P. is supported by NIH Fellowship 5 F32 Al 05281-02. Address reprint requests to Dr. Payne, Box 304, Mayo Memorial Building, 420 Delaware Street S.E., University of Minnesota Hospitals, Minneapolis, Minn. 55455.",

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AU - Michels, Lester D.

AU - Toledo-Pereyra, Luis H.

AU - Simmons, Richard L.

AU - Najarian, John S.

N1 - Funding Information: I Supported by USPHS Grants AM 13083 and Al 12754. W.D.P. is supported by NIH Fellowship 5 F32 Al 05281-02. Address reprint requests to Dr. Payne, Box 304, Mayo Memorial Building, 420 Delaware Street S.E., University of Minnesota Hospitals, Minneapolis, Minn. 55455.

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Y1 - 1977/4

N2 - The results in 190 consecutive perfused cadaver renal transplants failed to show a detrimental effect of long-term perfusion. In a controlled study in mongrel dogs, those receiving transplants preserved by pulsatile perfusion for 24 or 48 hr had equal or better survival than those receiving grafts preserved by cold storage or unpreserved grafts. In addition, kidneys preserved for 24 hr by perfusion showed functional abnormalities similar to those preserved as long by cold storage and those transplanted as fresh grafts. It can be concluded that pulsatile perfusion as a means of preservation does not adversely affect long-term function and does not increase the effective immunogenicity of renal allografts.

AB - The results in 190 consecutive perfused cadaver renal transplants failed to show a detrimental effect of long-term perfusion. In a controlled study in mongrel dogs, those receiving transplants preserved by pulsatile perfusion for 24 or 48 hr had equal or better survival than those receiving grafts preserved by cold storage or unpreserved grafts. In addition, kidneys preserved for 24 hr by perfusion showed functional abnormalities similar to those preserved as long by cold storage and those transplanted as fresh grafts. It can be concluded that pulsatile perfusion as a means of preservation does not adversely affect long-term function and does not increase the effective immunogenicity of renal allografts.

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Effects of pulsatile perfusion on the immunogenicity of renal allografts

Abstract

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