Effects of shear cell size on flowability of powders measured using a ring shear tester

Chenguang Wang; Sichen Song; Chamara A. Gunawardana; David J. Sun; Changquan Calvin Sun

doi:10.1016/j.powtec.2021.11.015

Effects of shear cell size on flowability of powders measured using a ring shear tester

Chenguang Wang, Sichen Song, Chamara A. Gunawardana, David J. Sun, Changquan Calvin Sun

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Flowability parameters of powders measured by a shear cell is expected to depend on shear cell size, but details of that effect are lacking. In this work, we have systematically evaluated this using a number of powders under three preshear normal stresses using a ring shear tester. The flowability index (ff_c) of a limestone powder (BCR 116) exhibited relatively small differences when measured on three shear cells of different sizes, S (~9.5 cm³) < M (~30 cm³) < L (~70 cm³). However, significant differences in measured ff_c of common pharmaceutical powders were observed, where ff_c of powders with a median particle size >22 μm was more than 15% higher using S than M. Large differences between data from M and L were found for powders with a median particle size >125 μm. Therefore, one must exercise caution when comparing flow properties of powders characterized using different shear cells.

Original language	English (US)
Pages (from-to)	555-564
Number of pages	10
Journal	Powder Technology
Volume	396
DOIs	https://doi.org/10.1016/j.powtec.2021.11.015
State	Published - Jan 2022

Bibliographical note

Funding Information:
A portion of this work was conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award ECCS-1542202.

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

Limestone
Mannitol
Microcrystalline cellulose
Powder flowability
Shear cell testing

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title = "Effects of shear cell size on flowability of powders measured using a ring shear tester",

abstract = "Flowability parameters of powders measured by a shear cell is expected to depend on shear cell size, but details of that effect are lacking. In this work, we have systematically evaluated this using a number of powders under three preshear normal stresses using a ring shear tester. The flowability index (ffc) of a limestone powder (BCR 116) exhibited relatively small differences when measured on three shear cells of different sizes, S (~9.5 cm3) < M (~30 cm3) < L (~70 cm3). However, significant differences in measured ffc of common pharmaceutical powders were observed, where ffc of powders with a median particle size >22 μm was more than 15% higher using S than M. Large differences between data from M and L were found for powders with a median particle size >125 μm. Therefore, one must exercise caution when comparing flow properties of powders characterized using different shear cells.",

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author = "Chenguang Wang and Sichen Song and Gunawardana, {Chamara A.} and Sun, {David J.} and Sun, {Changquan Calvin}",

note = "Funding Information: A portion of this work was conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award ECCS-1542202. Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

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doi = "10.1016/j.powtec.2021.11.015",

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AU - Wang, Chenguang

AU - Song, Sichen

AU - Gunawardana, Chamara A.

AU - Sun, David J.

AU - Sun, Changquan Calvin

N1 - Funding Information: A portion of this work was conducted in the Minnesota Nano Center, which is supported by the National Science Foundation through the National Nano Coordinated Infrastructure Network (NNCI) under Award ECCS-1542202. Publisher Copyright: © 2021 Elsevier B.V.

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Y1 - 2022/1

N2 - Flowability parameters of powders measured by a shear cell is expected to depend on shear cell size, but details of that effect are lacking. In this work, we have systematically evaluated this using a number of powders under three preshear normal stresses using a ring shear tester. The flowability index (ffc) of a limestone powder (BCR 116) exhibited relatively small differences when measured on three shear cells of different sizes, S (~9.5 cm3) < M (~30 cm3) < L (~70 cm3). However, significant differences in measured ffc of common pharmaceutical powders were observed, where ffc of powders with a median particle size >22 μm was more than 15% higher using S than M. Large differences between data from M and L were found for powders with a median particle size >125 μm. Therefore, one must exercise caution when comparing flow properties of powders characterized using different shear cells.

AB - Flowability parameters of powders measured by a shear cell is expected to depend on shear cell size, but details of that effect are lacking. In this work, we have systematically evaluated this using a number of powders under three preshear normal stresses using a ring shear tester. The flowability index (ffc) of a limestone powder (BCR 116) exhibited relatively small differences when measured on three shear cells of different sizes, S (~9.5 cm3) < M (~30 cm3) < L (~70 cm3). However, significant differences in measured ffc of common pharmaceutical powders were observed, where ffc of powders with a median particle size >22 μm was more than 15% higher using S than M. Large differences between data from M and L were found for powders with a median particle size >125 μm. Therefore, one must exercise caution when comparing flow properties of powders characterized using different shear cells.

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KW - Microcrystalline cellulose

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KW - Shear cell testing

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Effects of shear cell size on flowability of powders measured using a ring shear tester

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