TY - JOUR
T1 - Efficacy of yoga for vasomotor symptoms
T2 - A randomized controlled trial
AU - Newton, Katherine M.
AU - Reed, Susan D.
AU - Guthrie, Katherine A.
AU - Sherman, Karen J.
AU - Booth-Laforce, Cathryn
AU - Caan, Bette
AU - Sternfeld, Barbara
AU - Carpenter, Janet S.
AU - Learman, Lee A.
AU - Freeman, Ellen W.
AU - Cohen, Lee S.
AU - Joffe, Hadine
AU - Anderson, Garnet L.
AU - Larson, Joseph C.
AU - Hunt, Julie R.
AU - Ensrud, Kristine E.
AU - Lacroix, Andrea Z.
PY - 2014/4
Y1 - 2014/4
N2 - OBJECTIVE: This study aims to determine the efficacy of yoga in alleviating vasomotor symptoms (VMS) frequency and bother. METHODS: This study was a three-by-two factorial, randomized controlled trial. Eligible women were randomized to yoga (n = 107), exercise (n = 106), or usual activity (n = 142), and were simultaneously randomized to a double-blind comparison of ω-3 fatty acid (n = 177) or placebo (n = 178) capsules. Yoga intervention consisted of 12 weekly 90-minute yoga classes with daily home practice. Primary outcomes were VMS frequency and bother assessed by daily diaries at baseline, 6 weeks, and 12 weeks. Secondary outcomes included insomnia symptoms (Insomnia Severity Index) at baseline and 12 weeks. RESULTS: Among 249 randomized women, 237 (95%) completed 12-week assessments. The mean baseline VMS frequency was 7.4 per day (95% CI, 6.6 to 8.1) in the yoga group and 8.0 per day (95% CI, 7.3 to 8.7) in the usual activity group. Intent-to-treat analyses included all participants with response data (n = 237). There was no difference between intervention groups in the change in VMS frequency from baseline to 6 and 12 weeks (mean difference [yoga-usual activity] from baseline at 6 wk,-0.3 [95% CI,-1.1 to 0.5]; mean difference [yoga-usual activity] from baseline at 12 wk,-0.3 [95% CI,-1.2 to 0.6]; P = 0.119 across both time points). Results were similar for VMS bother. At week 12, yoga was associated with an improvement in insomnia symptoms (mean difference [yoga-usual activity] in the change in Insomnia Severity Index, 1.3 [95% CI,-2.5 to-0.1]; P = 0.007). CONCLUSIONS: Among healthy women, 12 weeks of yoga class plus home practice, compared with usual activity, do not improve VMS frequency or bother but reduce insomnia symptoms.
AB - OBJECTIVE: This study aims to determine the efficacy of yoga in alleviating vasomotor symptoms (VMS) frequency and bother. METHODS: This study was a three-by-two factorial, randomized controlled trial. Eligible women were randomized to yoga (n = 107), exercise (n = 106), or usual activity (n = 142), and were simultaneously randomized to a double-blind comparison of ω-3 fatty acid (n = 177) or placebo (n = 178) capsules. Yoga intervention consisted of 12 weekly 90-minute yoga classes with daily home practice. Primary outcomes were VMS frequency and bother assessed by daily diaries at baseline, 6 weeks, and 12 weeks. Secondary outcomes included insomnia symptoms (Insomnia Severity Index) at baseline and 12 weeks. RESULTS: Among 249 randomized women, 237 (95%) completed 12-week assessments. The mean baseline VMS frequency was 7.4 per day (95% CI, 6.6 to 8.1) in the yoga group and 8.0 per day (95% CI, 7.3 to 8.7) in the usual activity group. Intent-to-treat analyses included all participants with response data (n = 237). There was no difference between intervention groups in the change in VMS frequency from baseline to 6 and 12 weeks (mean difference [yoga-usual activity] from baseline at 6 wk,-0.3 [95% CI,-1.1 to 0.5]; mean difference [yoga-usual activity] from baseline at 12 wk,-0.3 [95% CI,-1.2 to 0.6]; P = 0.119 across both time points). Results were similar for VMS bother. At week 12, yoga was associated with an improvement in insomnia symptoms (mean difference [yoga-usual activity] in the change in Insomnia Severity Index, 1.3 [95% CI,-2.5 to-0.1]; P = 0.007). CONCLUSIONS: Among healthy women, 12 weeks of yoga class plus home practice, compared with usual activity, do not improve VMS frequency or bother but reduce insomnia symptoms.
KW - Clinical Trials Network
KW - Hot flashes
KW - Meditation
KW - Menopause
KW - Vasomotor symptoms
KW - Yoga
UR - http://www.scopus.com/inward/record.url?scp=84897503614&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897503614&partnerID=8YFLogxK
U2 - 10.1097/GME.0b013e31829e4baa
DO - 10.1097/GME.0b013e31829e4baa
M3 - Article
C2 - 24045673
AN - SCOPUS:84897503614
SN - 1072-3714
VL - 21
SP - 339
EP - 346
JO - Menopause
JF - Menopause
IS - 4
ER -