TY - JOUR
T1 - Efflux Limits Tumor Drug Delivery Despite Disrupted BBB
AU - Griffith, Jessica I.
AU - Sarkaria, Jann N.
AU - Elmquist, William F.
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/6
Y1 - 2021/6
N2 - Apparent blood–brain barrier (BBB) disruption is common in glioblastoma (GBM), but has not translated to improved drug delivery efficacy. Recently, de Gooijer et al. demonstrated that efflux transporters can have a prominent role in limiting drug delivery. These transport systems contribute to ineffective drug delivery to tumor cells in the brain.
AB - Apparent blood–brain barrier (BBB) disruption is common in glioblastoma (GBM), but has not translated to improved drug delivery efficacy. Recently, de Gooijer et al. demonstrated that efflux transporters can have a prominent role in limiting drug delivery. These transport systems contribute to ineffective drug delivery to tumor cells in the brain.
UR - http://www.scopus.com/inward/record.url?scp=85102653589&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85102653589&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2021.03.001
DO - 10.1016/j.tips.2021.03.001
M3 - Short survey
C2 - 33736874
AN - SCOPUS:85102653589
SN - 0165-6147
VL - 42
SP - 426
EP - 428
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 6
ER -
