Emerging technologies and ethics—exogenic chimeric humanized organs

Mary G. Garry; Arthur L. Caplan; Daniel J. Garry

doi:10.1111/ajt.17188

Emerging technologies and ethics—exogenic chimeric humanized organs

Mary G. Garry, Arthur L. Caplan, Daniel J. Garry

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

Abstract

Organ transplantation is limited due to the scarcity of donor organs. In order to expand the supply of organs for transplantation, interspecies chimeras have been examined as a potential future source of humanized organs. Recent studies using gene editing technologies in combination with somatic cell nuclear transfer technology and hiPSCs successfully engineered humanized skeletal muscle in the porcine embryo. As these technologies progress, there are ethical issues that warrant consideration and dialogue.

Original language	English (US)
Pages (from-to)	2786-2790
Number of pages	5
Journal	American Journal of Transplantation
Volume	22
Issue number	12
DOIs	https://doi.org/10.1111/ajt.17188
State	Published - Dec 2022

Bibliographical note

Funding Information:
DJG is supported by grants from RMM and the DoD. MGG is supported by grant funding from the DoD. The authors have no other financial disclosures as described by the American Journal of Transplantation.

Publisher Copyright:
© 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.

Keywords

editorial
ethics and public policy
personal viewpoint

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

Access

10.1111/ajt.17188

OpenUrl availability

Full text

Cite this

@article{1c7e2ad1cd524f299208a7844a04c46f,

title = "Emerging technologies and ethics—exogenic chimeric humanized organs",

abstract = "Organ transplantation is limited due to the scarcity of donor organs. In order to expand the supply of organs for transplantation, interspecies chimeras have been examined as a potential future source of humanized organs. Recent studies using gene editing technologies in combination with somatic cell nuclear transfer technology and hiPSCs successfully engineered humanized skeletal muscle in the porcine embryo. As these technologies progress, there are ethical issues that warrant consideration and dialogue.",

keywords = "editorial, ethics and public policy, personal viewpoint",

author = "Garry, {Mary G.} and Caplan, {Arthur L.} and Garry, {Daniel J.}",

note = "Funding Information: DJG is supported by grants from RMM and the DoD. MGG is supported by grant funding from the DoD. The authors have no other financial disclosures as described by the American Journal of Transplantation. Publisher Copyright: {\textcopyright} 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.",

year = "2022",

month = dec,

doi = "10.1111/ajt.17188",

language = "English (US)",

volume = "22",

pages = "2786--2790",

journal = "American Journal of Transplantation",

issn = "1600-6135",

publisher = "Wiley-Blackwell",

number = "12",

}

TY - JOUR

T1 - Emerging technologies and ethics—exogenic chimeric humanized organs

AU - Garry, Mary G.

AU - Caplan, Arthur L.

AU - Garry, Daniel J.

N1 - Funding Information: DJG is supported by grants from RMM and the DoD. MGG is supported by grant funding from the DoD. The authors have no other financial disclosures as described by the American Journal of Transplantation. Publisher Copyright: © 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.

PY - 2022/12

Y1 - 2022/12

N2 - Organ transplantation is limited due to the scarcity of donor organs. In order to expand the supply of organs for transplantation, interspecies chimeras have been examined as a potential future source of humanized organs. Recent studies using gene editing technologies in combination with somatic cell nuclear transfer technology and hiPSCs successfully engineered humanized skeletal muscle in the porcine embryo. As these technologies progress, there are ethical issues that warrant consideration and dialogue.

AB - Organ transplantation is limited due to the scarcity of donor organs. In order to expand the supply of organs for transplantation, interspecies chimeras have been examined as a potential future source of humanized organs. Recent studies using gene editing technologies in combination with somatic cell nuclear transfer technology and hiPSCs successfully engineered humanized skeletal muscle in the porcine embryo. As these technologies progress, there are ethical issues that warrant consideration and dialogue.

KW - editorial

KW - ethics and public policy

KW - personal viewpoint

UR - http://www.scopus.com/inward/record.url?scp=85137911482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85137911482&partnerID=8YFLogxK

U2 - 10.1111/ajt.17188

DO - 10.1111/ajt.17188

M3 - Article

C2 - 36052557

AN - SCOPUS:85137911482

SN - 1600-6135

VL - 22

SP - 2786

EP - 2790

JO - American Journal of Transplantation

JF - American Journal of Transplantation

IS - 12

ER -

Emerging technologies and ethics—exogenic chimeric humanized organs

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this