Enhanced neutralizing antibody responses to rhinovirus c and age-dependent patterns of infection

Timothy Choi; Mark Devries; Leonard B. Bacharier; William Busse; Carlos A. Camargo; Robyn Cohen; Gregory P. Demuri; Michael D. Evans; Anne M. Fitzpatrick; Peter J. Gergen; Kristine Grindle; Rebecca Gruchalla; Tina Hartert; Kohei Hasegawa; Gurjit K.Khurana Hershey; Patrick Holt; Kiara Homil; Tuomas Jartti; Meyer Kattan; Carolyn Kercsmar; Haejin Kim; Ingrid A. Laing; Petra LeBeau; Kristine E. Lee; Peter N. Le Souëf; Andrew Liu; David T. Mauger; Carole Ober; Tressa Pappas; Shilpa J. Patel; Wanda Phipatanakul; Jacqueline Pongracic; Christine Seroogy; Peter D. Sly; Christopher Tisler; Ellen R. Wald; Robert Wood; Ronald Gangnon; Daniel J. Jackson; Robert F. Lemanske; James E. Gern; Yury A. Bochkov

doi:10.1164/rccm.202010-3753OC

Enhanced neutralizing antibody responses to rhinovirus c and age-dependent patterns of infection

Timothy Choi, Mark Devries, Leonard B. Bacharier, William Busse, Carlos A. Camargo, Robyn Cohen, Gregory P. Demuri, Michael D. Evans, Anne M. Fitzpatrick, Peter J. Gergen, Kristine Grindle, Rebecca Gruchalla, Tina Hartert, Kohei Hasegawa, Gurjit K.Khurana Hershey, Patrick Holt, Kiara Homil, Tuomas Jartti, Meyer Kattan, Carolyn KercsmarHaejin Kim, Ingrid A. Laing, Petra LeBeau, Kristine E. Lee, Peter N. Le Souëf, Andrew Liu, David T. Mauger, Carole Ober, Tressa Pappas, Shilpa J. Patel, Wanda Phipatanakul, Jacqueline Pongracic, Christine Seroogy, Peter D. Sly, Christopher Tisler, Ellen R. Wald, Robert Wood, Ronald Gangnon, Daniel J. Jackson, Robert F. Lemanske, James E. Gern, Yury A. Bochkov

CTSI Biostatistics

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Rationale: Rhinovirus (RV) C can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing. Objectives: To identify how age and other individual-level factors are associated with susceptibility to RV-C illnesses. Methods: Longitudinal data from the COAST (Childhood Origins of Asthma) birth cohort study were analyzed to determine relationships between age and RV-C infections. Neutralizing antibodies specific for RV-A and RV-C (three types each) were determined using a novel PCR-based assay. Data were pooled from 14 study cohorts in the United States, Finland, and Australia, and mixed-effects logistic regression was used to identify factors related to the proportion of RV-C versus RV-A detection. Measurements and Main Results: In COAST, RV-A and RV-C infections were similarly common in infancy, whereas RV-C was detected muchless oftenthanRV-Aduring bothrespiratory illnesses andscheduled surveillance visits (P<0.001, x2) in older children. The prevalence of neutralizingantibodies toRV-AorRV-Ctypeswas low(5-27%) at the age of 2 years, but by the age of 16 years, RV-C seropositivity was more prevalent (78%vs. 18%for RV-A; P<0.0001). In the pooled analysis, the RV-C to RV-A detection ratio during illnesses was significantly related to age (P<0.0001), CDHR3 genotype (P<0.05), and wheezing illnesses (P<0.05). Furthermore, certain RV types (e.g., C2, C11, A78, and A12) were consistently more virulent and prevalent over time. Conclusions: Knowledge of prevalent RV types, antibody responses, and populations at risk based on age and genetics may guide the development of vaccines or other novel therapies against this important respiratory pathogen.

Original language	English (US)
Pages (from-to)	822-830
Number of pages	9
Journal	American journal of respiratory and critical care medicine
Volume	203
Issue number	7
DOIs	https://doi.org/10.1164/rccm.202010-3753OC
State	Published - Apr 1 2021

Bibliographical note

Funding Information:
Supported by the Environmental Influences on Child Health Outcomes program, Office of The Director, NIH, under award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (Person-Reported Outcome [PRO] Core), UG3/UH3 OD023282, and UG3/UH3 OD-023253; NIH grants R01AI148707, P01 HL070831, UM1 AI114271, R01 AI-114552, R01 AI-127507, U19 AI095227, UL1 RR024975, and R01-AI097172; the Sigrid Juselius Foundation, Helsinki, Finland; National Health and Medical Research Council grants 211912, 458513; and by grants APP1045760, APP1087700, APP1129996, APP1147630. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH and other funding agencies.

Publisher Copyright:
© 2021 by the American Thoracic Society.

Keywords

CDHR3
Epidemiology
Genetics
Rhinovirus
Wheezing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1164/rccm.202010-3753OC

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Choi, T., Devries, M., Bacharier, L. B., Busse, W., Camargo, C. A., Cohen, R., Demuri, G. P., Evans, M. D., Fitzpatrick, A. M., Gergen, P. J., Grindle, K., Gruchalla, R., Hartert, T., Hasegawa, K., Hershey, G. K. K., Holt, P., Homil, K., Jartti, T., Kattan, M., ... Bochkov, Y. A. (2021). Enhanced neutralizing antibody responses to rhinovirus c and age-dependent patterns of infection. American journal of respiratory and critical care medicine, 203(7), 822-830. https://doi.org/10.1164/rccm.202010-3753OC

Choi, T, Devries, M, Bacharier, LB, Busse, W, Camargo, CA, Cohen, R, Demuri, GP, Evans, MD, Fitzpatrick, AM, Gergen, PJ, Grindle, K, Gruchalla, R, Hartert, T, Hasegawa, K, Hershey, GKK, Holt, P, Homil, K, Jartti, T, Kattan, M, Kercsmar, C, Kim, H, Laing, IA, LeBeau, P, Lee, KE, Le Souëf, PN, Liu, A, Mauger, DT, Ober, C, Pappas, T, Patel, SJ, Phipatanakul, W, Pongracic, J, Seroogy, C, Sly, PD, Tisler, C, Wald, ER, Wood, R, Gangnon, R, Jackson, DJ, Lemanske, RF, Gern, JE & Bochkov, YA 2021, 'Enhanced neutralizing antibody responses to rhinovirus c and age-dependent patterns of infection', American journal of respiratory and critical care medicine, vol. 203, no. 7, pp. 822-830. https://doi.org/10.1164/rccm.202010-3753OC

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title = "Enhanced neutralizing antibody responses to rhinovirus c and age-dependent patterns of infection",

abstract = "Rationale: Rhinovirus (RV) C can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing. Objectives: To identify how age and other individual-level factors are associated with susceptibility to RV-C illnesses. Methods: Longitudinal data from the COAST (Childhood Origins of Asthma) birth cohort study were analyzed to determine relationships between age and RV-C infections. Neutralizing antibodies specific for RV-A and RV-C (three types each) were determined using a novel PCR-based assay. Data were pooled from 14 study cohorts in the United States, Finland, and Australia, and mixed-effects logistic regression was used to identify factors related to the proportion of RV-C versus RV-A detection. Measurements and Main Results: In COAST, RV-A and RV-C infections were similarly common in infancy, whereas RV-C was detected muchless oftenthanRV-Aduring bothrespiratory illnesses andscheduled surveillance visits (P<0.001, x2) in older children. The prevalence of neutralizingantibodies toRV-AorRV-Ctypeswas low(5-27%) at the age of 2 years, but by the age of 16 years, RV-C seropositivity was more prevalent (78%vs. 18%for RV-A; P<0.0001). In the pooled analysis, the RV-C to RV-A detection ratio during illnesses was significantly related to age (P<0.0001), CDHR3 genotype (P<0.05), and wheezing illnesses (P<0.05). Furthermore, certain RV types (e.g., C2, C11, A78, and A12) were consistently more virulent and prevalent over time. Conclusions: Knowledge of prevalent RV types, antibody responses, and populations at risk based on age and genetics may guide the development of vaccines or other novel therapies against this important respiratory pathogen.",

keywords = "CDHR3, Epidemiology, Genetics, Rhinovirus, Wheezing",

author = "Timothy Choi and Mark Devries and Bacharier, {Leonard B.} and William Busse and Camargo, {Carlos A.} and Robyn Cohen and Demuri, {Gregory P.} and Evans, {Michael D.} and Fitzpatrick, {Anne M.} and Gergen, {Peter J.} and Kristine Grindle and Rebecca Gruchalla and Tina Hartert and Kohei Hasegawa and Hershey, {Gurjit K.Khurana} and Patrick Holt and Kiara Homil and Tuomas Jartti and Meyer Kattan and Carolyn Kercsmar and Haejin Kim and Laing, {Ingrid A.} and Petra LeBeau and Lee, {Kristine E.} and {Le Sou{\"e}f}, {Peter N.} and Andrew Liu and Mauger, {David T.} and Carole Ober and Tressa Pappas and Patel, {Shilpa J.} and Wanda Phipatanakul and Jacqueline Pongracic and Christine Seroogy and Sly, {Peter D.} and Christopher Tisler and Wald, {Ellen R.} and Robert Wood and Ronald Gangnon and Jackson, {Daniel J.} and Lemanske, {Robert F.} and Gern, {James E.} and Bochkov, {Yury A.}",

note = "Funding Information: Supported by the Environmental Influences on Child Health Outcomes program, Office of The Director, NIH, under award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (Person-Reported Outcome [PRO] Core), UG3/UH3 OD023282, and UG3/UH3 OD-023253; NIH grants R01AI148707, P01 HL070831, UM1 AI114271, R01 AI-114552, R01 AI-127507, U19 AI095227, UL1 RR024975, and R01-AI097172; the Sigrid Juselius Foundation, Helsinki, Finland; National Health and Medical Research Council grants 211912, 458513; and by grants APP1045760, APP1087700, APP1129996, APP1147630. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH and other funding agencies. Publisher Copyright: {\textcopyright} 2021 by the American Thoracic Society.",

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doi = "10.1164/rccm.202010-3753OC",

language = "English (US)",

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TY - JOUR

T1 - Enhanced neutralizing antibody responses to rhinovirus c and age-dependent patterns of infection

AU - Choi, Timothy

AU - Devries, Mark

AU - Bacharier, Leonard B.

AU - Busse, William

AU - Camargo, Carlos A.

AU - Cohen, Robyn

AU - Demuri, Gregory P.

AU - Evans, Michael D.

AU - Fitzpatrick, Anne M.

AU - Gergen, Peter J.

AU - Grindle, Kristine

AU - Gruchalla, Rebecca

AU - Hartert, Tina

AU - Hasegawa, Kohei

AU - Hershey, Gurjit K.Khurana

AU - Holt, Patrick

AU - Homil, Kiara

AU - Jartti, Tuomas

AU - Kattan, Meyer

AU - Kercsmar, Carolyn

AU - Kim, Haejin

AU - Laing, Ingrid A.

AU - LeBeau, Petra

AU - Lee, Kristine E.

AU - Le Souëf, Peter N.

AU - Liu, Andrew

AU - Mauger, David T.

AU - Ober, Carole

AU - Pappas, Tressa

AU - Patel, Shilpa J.

AU - Phipatanakul, Wanda

AU - Pongracic, Jacqueline

AU - Seroogy, Christine

AU - Sly, Peter D.

AU - Tisler, Christopher

AU - Wald, Ellen R.

AU - Wood, Robert

AU - Gangnon, Ronald

AU - Jackson, Daniel J.

AU - Lemanske, Robert F.

AU - Gern, James E.

AU - Bochkov, Yury A.

N1 - Funding Information: Supported by the Environmental Influences on Child Health Outcomes program, Office of The Director, NIH, under award numbers U2COD023375 (Coordinating Center), U24OD023382 (Data Analysis Center), U24OD023319 (Person-Reported Outcome [PRO] Core), UG3/UH3 OD023282, and UG3/UH3 OD-023253; NIH grants R01AI148707, P01 HL070831, UM1 AI114271, R01 AI-114552, R01 AI-127507, U19 AI095227, UL1 RR024975, and R01-AI097172; the Sigrid Juselius Foundation, Helsinki, Finland; National Health and Medical Research Council grants 211912, 458513; and by grants APP1045760, APP1087700, APP1129996, APP1147630. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH and other funding agencies. Publisher Copyright: © 2021 by the American Thoracic Society.

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Rationale: Rhinovirus (RV) C can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing. Objectives: To identify how age and other individual-level factors are associated with susceptibility to RV-C illnesses. Methods: Longitudinal data from the COAST (Childhood Origins of Asthma) birth cohort study were analyzed to determine relationships between age and RV-C infections. Neutralizing antibodies specific for RV-A and RV-C (three types each) were determined using a novel PCR-based assay. Data were pooled from 14 study cohorts in the United States, Finland, and Australia, and mixed-effects logistic regression was used to identify factors related to the proportion of RV-C versus RV-A detection. Measurements and Main Results: In COAST, RV-A and RV-C infections were similarly common in infancy, whereas RV-C was detected muchless oftenthanRV-Aduring bothrespiratory illnesses andscheduled surveillance visits (P<0.001, x2) in older children. The prevalence of neutralizingantibodies toRV-AorRV-Ctypeswas low(5-27%) at the age of 2 years, but by the age of 16 years, RV-C seropositivity was more prevalent (78%vs. 18%for RV-A; P<0.0001). In the pooled analysis, the RV-C to RV-A detection ratio during illnesses was significantly related to age (P<0.0001), CDHR3 genotype (P<0.05), and wheezing illnesses (P<0.05). Furthermore, certain RV types (e.g., C2, C11, A78, and A12) were consistently more virulent and prevalent over time. Conclusions: Knowledge of prevalent RV types, antibody responses, and populations at risk based on age and genetics may guide the development of vaccines or other novel therapies against this important respiratory pathogen.

AB - Rationale: Rhinovirus (RV) C can cause asymptomatic infection and respiratory illnesses ranging from the common cold to severe wheezing. Objectives: To identify how age and other individual-level factors are associated with susceptibility to RV-C illnesses. Methods: Longitudinal data from the COAST (Childhood Origins of Asthma) birth cohort study were analyzed to determine relationships between age and RV-C infections. Neutralizing antibodies specific for RV-A and RV-C (three types each) were determined using a novel PCR-based assay. Data were pooled from 14 study cohorts in the United States, Finland, and Australia, and mixed-effects logistic regression was used to identify factors related to the proportion of RV-C versus RV-A detection. Measurements and Main Results: In COAST, RV-A and RV-C infections were similarly common in infancy, whereas RV-C was detected muchless oftenthanRV-Aduring bothrespiratory illnesses andscheduled surveillance visits (P<0.001, x2) in older children. The prevalence of neutralizingantibodies toRV-AorRV-Ctypeswas low(5-27%) at the age of 2 years, but by the age of 16 years, RV-C seropositivity was more prevalent (78%vs. 18%for RV-A; P<0.0001). In the pooled analysis, the RV-C to RV-A detection ratio during illnesses was significantly related to age (P<0.0001), CDHR3 genotype (P<0.05), and wheezing illnesses (P<0.05). Furthermore, certain RV types (e.g., C2, C11, A78, and A12) were consistently more virulent and prevalent over time. Conclusions: Knowledge of prevalent RV types, antibody responses, and populations at risk based on age and genetics may guide the development of vaccines or other novel therapies against this important respiratory pathogen.

KW - CDHR3

KW - Epidemiology

KW - Genetics

KW - Rhinovirus

KW - Wheezing

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Enhanced neutralizing antibody responses to rhinovirus c and age-dependent patterns of infection

Abstract

Bibliographical note

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UN SDGs

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