Abstract
In order to study the ability of the enzyme adenosine deaminase to tolerate bulk at the 6-position of certain purine nucleoside analogs, several 6-substituted amino-9-(3-hydroxypropyl)purines were prepared. These compounds were synthesized by allowing 6-chloro-9-(3-hydroxypropyl)purine to react with the appropriate amines. Enzymatic evaluation of these compounds revealed that increasing the size of the substituent on the 6-amino group decreased the inhibitory property of the compound. These results establish that adenosine deaminase has little bulk tolerance for substituents on the 6-amino group of the purine nucleus.
Original language | English (US) |
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Pages (from-to) | 33-35 |
Number of pages | 3 |
Journal | Journal of Medicinal Chemistry |
Volume | 8 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1965 |
Externally published | Yes |