TY - JOUR
T1 - Epidemiology and genetics of early onset colorectal cancer—African overview with a focus on Ethiopia
AU - Anugwom, Chimaobi
AU - Braimoh, Grace
AU - Sultan, Amir
AU - Johnson, Willie Mohammed
AU - Debes, Jose D.
AU - Mohammed, Abdulsemed
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Colorectal cancer (CRC) is a common cause of cancer-related death worldwide, with high rates of late diagnosis and increased mortality in sub-Saharan Africa. Furthermore, there is an alarming uptrend in the incidence of early onset colorectal cancer (EOCRC) across the globe, thus necessitating the need for early screening in general and special populations. There is, however, limited data available on the incidence and genetic characteristics of EOCRC from resource-poor countries, particularly Africa. Moreover, there is lack of clarity if recommendations and mechanisms proposed based on data from resource-rich countries applies to other regions of the world. In this review, we appraise the literature on EOCRC, its overall incidence, and genetic components as it pertains to sub-Saharan Africa. In addition, we highlight epidemiologic and epigenetic findings of our EOCRC cohort in Ethiopia.
AB - Colorectal cancer (CRC) is a common cause of cancer-related death worldwide, with high rates of late diagnosis and increased mortality in sub-Saharan Africa. Furthermore, there is an alarming uptrend in the incidence of early onset colorectal cancer (EOCRC) across the globe, thus necessitating the need for early screening in general and special populations. There is, however, limited data available on the incidence and genetic characteristics of EOCRC from resource-poor countries, particularly Africa. Moreover, there is lack of clarity if recommendations and mechanisms proposed based on data from resource-rich countries applies to other regions of the world. In this review, we appraise the literature on EOCRC, its overall incidence, and genetic components as it pertains to sub-Saharan Africa. In addition, we highlight epidemiologic and epigenetic findings of our EOCRC cohort in Ethiopia.
KW - Colorectal cancer
KW - Early
KW - Ethiopia
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U2 - 10.1053/j.seminoncol.2023.03.007
DO - 10.1053/j.seminoncol.2023.03.007
M3 - Review article
C2 - 37032270
AN - SCOPUS:85152390090
SN - 0093-7754
VL - 50
SP - 28
EP - 33
JO - Seminars in Oncology
JF - Seminars in Oncology
IS - 1-2
ER -