TY - JOUR
T1 - Evaluation of periodontal treatments using controlled-release tetracycline fibers
T2 - Maintenance response
AU - Michalowicz, B. S.
AU - Pihlstrom, B. L.
AU - Drisko, C. L.
AU - Cobb, C. M.
AU - Killoy, W. J.
AU - Caton, J. G.
AU - Lowenguth, R. A.
AU - Quinones, C.
AU - Encarnacion, M.
AU - Knowles, M.
AU - Goodson, J. M.
PY - 1995
Y1 - 1995
N2 - The purpose of this investigation was to examine periodontal disease recurrence from 3 to 12 months following various treatments with scaling and root planing and controlled-release tetracycline fibers. One-hundred-twenty-two (122) adult volunteers with at least one bleeding pocket ≥5 mm in each of four quadrants were enrolled in this study. One or two such sites in each quadrant were selected as test sites. Quadrants were randomly assigned to receive one of four treatments: scaling and root planing (S); scaling and root planing plus tetracycline fiber for 10 days (SF); fiber therapy alone for 10 days (F); or fiber therapy alone for 20 days (FF). After treatment, no supportive care was provided during the 12-month study period. probing depth (PD), attachment loss (AL), plaque, and bleeding on probing were measured at baseline, and at 1, 3, 6, 9, and 12 months after treatment. PD and AL measures were taken at three locations within each site and averaged for each site. Disease recurrence was defined as ≥1 mm mean attachment loss at a site during the 3- to 12-month period. One-hundred-sixteen (116) subjects completed the study. Sites treated with SF experienced significantly (P < 0.05) less disease recurrence (4%) than S, F, or FF (9%, 10%, and 12%, respectively). Results of this study suggest that, compared to S, F, or FF, scaling and root planning in conjunction with tetracycline fiber therapy for 10 days can significantly reduce disease recurrence 3 to 12 months following treatment in the absence of supportive care.
AB - The purpose of this investigation was to examine periodontal disease recurrence from 3 to 12 months following various treatments with scaling and root planing and controlled-release tetracycline fibers. One-hundred-twenty-two (122) adult volunteers with at least one bleeding pocket ≥5 mm in each of four quadrants were enrolled in this study. One or two such sites in each quadrant were selected as test sites. Quadrants were randomly assigned to receive one of four treatments: scaling and root planing (S); scaling and root planing plus tetracycline fiber for 10 days (SF); fiber therapy alone for 10 days (F); or fiber therapy alone for 20 days (FF). After treatment, no supportive care was provided during the 12-month study period. probing depth (PD), attachment loss (AL), plaque, and bleeding on probing were measured at baseline, and at 1, 3, 6, 9, and 12 months after treatment. PD and AL measures were taken at three locations within each site and averaged for each site. Disease recurrence was defined as ≥1 mm mean attachment loss at a site during the 3- to 12-month period. One-hundred-sixteen (116) subjects completed the study. Sites treated with SF experienced significantly (P < 0.05) less disease recurrence (4%) than S, F, or FF (9%, 10%, and 12%, respectively). Results of this study suggest that, compared to S, F, or FF, scaling and root planning in conjunction with tetracycline fiber therapy for 10 days can significantly reduce disease recurrence 3 to 12 months following treatment in the absence of supportive care.
KW - clinical trials
KW - periodontitis/therapy
KW - planning
KW - scaling
KW - tetracycline/therapeutic use
UR - http://www.scopus.com/inward/record.url?scp=0029092082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029092082&partnerID=8YFLogxK
U2 - 10.1902/jop.1995.66.8.708
DO - 10.1902/jop.1995.66.8.708
M3 - Article
C2 - 7473014
AN - SCOPUS:0029092082
SN - 0022-3492
VL - 66
SP - 708
EP - 715
JO - Journal of periodontology
JF - Journal of periodontology
IS - 8
ER -