Ex vivo elimination of neoplastic T-cells from human marrow using an anti-Mr 41,000 protein immunotoxin: Potentiation by ASTA Z 7557

F. M. Uckun; Sundaram Ramakrishnan; L. L. Houston

doi:10.1007/BF00319765

Ex vivo elimination of neoplastic T-cells from human marrow using an anti-M_r 41,000 protein immunotoxin: Potentiation by ASTA Z 7557

F. M. Uckun, Sundaram Ramakrishnan, L. L. Houston

Pharmacology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

ASTA Z 7557 potentiated the ex vivo efficiency of a T-cell directed immunotoxin containing pokeweed antiviral protein (PAP). We used an immunotoxin of pan-T monoclonal antibody 3-Al directed against p41 antigen expressed both on normal and leukemic T-cells. Treatment with 3Al-PAP in combination with ASTA Z 7557 produced 7-8 logs elimination of target lymphoblastic leukemia cells. Our data suggest that this new strategy shows potential for more effective ex vivo marrow purging in autologous marrow transplantation for acute lymphoblastic leukemia.

Original language	English (US)
Pages (from-to)	19-23
Number of pages	5
Journal	Blut
Volume	50
Issue number	1
DOIs	https://doi.org/10.1007/BF00319765
State	Published - Jan 1985

Keywords

ASTA Z 7557
Immunotoxin
autologous bone marrow transplantation
pokeweed antiviral protein

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