Exaggerated cardiovascular and behavioral nociceptive responses to subcutaneous formalin in the spontaneously hypertensive rat

Bradley K. Taylor; M. Alex Peterson; Allan I. Basbaum

doi:10.1016/0304-3940(95)12157-Y

Exaggerated cardiovascular and behavioral nociceptive responses to subcutaneous formalin in the spontaneously hypertensive rat

Bradley K. Taylor, M. Alex Peterson, Allan I. Basbaum

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Abstract

Spontaneously hypertensive rats (SHRs) are typically less responsive to phasic noxious stimuli than are their normotensive controls. Here, we used the formalin test to compare behavioral and cardiovascular responses to persistent noxious stimuli. Hindpaw formalin injection produced exaggerated flinching, arterial pressure and heart rate responses in SHRs, suggesting that abnormalities in blood pressure control systems increase nociceptive responses to persistent noxious stimuli.

Original language	English (US)
Pages (from-to)	9-12
Number of pages	4
Journal	Neuroscience Letters
Volume	201
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(95)12157-Y
State	Published - Dec 1 1995
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by grants NS21445 and DA 08377. Dr. Taylor was a postdoctoral fellow supported by Training Grant NS07265.

Keywords

Blood pressure
Formalin
Heart rate
Hyperalgesia
Nociception
Spontaneously hypertensive rat

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title = "Exaggerated cardiovascular and behavioral nociceptive responses to subcutaneous formalin in the spontaneously hypertensive rat",

abstract = "Spontaneously hypertensive rats (SHRs) are typically less responsive to phasic noxious stimuli than are their normotensive controls. Here, we used the formalin test to compare behavioral and cardiovascular responses to persistent noxious stimuli. Hindpaw formalin injection produced exaggerated flinching, arterial pressure and heart rate responses in SHRs, suggesting that abnormalities in blood pressure control systems increase nociceptive responses to persistent noxious stimuli.",

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AU - Basbaum, Allan I.

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AB - Spontaneously hypertensive rats (SHRs) are typically less responsive to phasic noxious stimuli than are their normotensive controls. Here, we used the formalin test to compare behavioral and cardiovascular responses to persistent noxious stimuli. Hindpaw formalin injection produced exaggerated flinching, arterial pressure and heart rate responses in SHRs, suggesting that abnormalities in blood pressure control systems increase nociceptive responses to persistent noxious stimuli.

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KW - Heart rate

KW - Hyperalgesia

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Exaggerated cardiovascular and behavioral nociceptive responses to subcutaneous formalin in the spontaneously hypertensive rat

Abstract

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Keywords

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