Abstract
Introduction: Current bioinks for 3D bioprinting, such as gelatin-methacryloyl, are generally low viscosity fluids at room temperature, requiring specialized systems to create complex geometries. Methods and Results: Adding decellularized extracellular matrix microparticles derived from porcine tracheal cartilage to gelatin-methacryloyl creates a yield stress fluid capable of forming self-supporting structures. This bioink blend performs similarly at 25 °C to gelatin-methacryloyl alone at 15 °C in linear resolution, print fidelity, and tensile mechanics. Conclusion: This method lowers barriers to manufacturing complex tissue geometries and removes the need for cooling systems.
Original language | English (US) |
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Article number | 2200196 |
Journal | Macromolecular Materials and Engineering |
Volume | 307 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2022 |
Bibliographical note
Publisher Copyright:© 2022 The Authors. Macromolecular Materials and Engineering published by Wiley-VCH GmbH.
Keywords
- 3D bioprinting
- extracellular matrix
- hydrogels
- larynx
- tissue engineering
- trachea
PubMed: MeSH publication types
- Journal Article