“False negative” CSF cryptococcal antigen with clinical meningitis: Case reports and review of literature

Morris K. Rutakingirwa; Tadeo K. Kiiza; Joshua Rhein

doi:10.1016/j.mmcr.2020.06.003

“False negative” CSF cryptococcal antigen with clinical meningitis: Case reports and review of literature

Morris K. Rutakingirwa, Tadeo K. Kiiza, Joshua Rhein

Medicine - Infectious Disease and International

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11 Scopus citations

Abstract

There is an increasing recognition of patients presenting with cryptococcal meningitis despite having a negative CSF cryptococcal antigen (CrAg). In this report, we describe three cases of patients with advanced immunosuppression who presented to hospital with “false negative” CSF cryptococcal antigen, two of whom had a positive fungal culture. We describe the challenge of CSF-CrAg negative cryptococcal meningitis and explore ways to overcome this challenge using newer diagnostic techniques.

Original language	English (US)
Pages (from-to)	29-31
Number of pages	3
Journal	Medical Mycology Case Reports
Volume	29
DOIs	https://doi.org/10.1016/j.mmcr.2020.06.003
State	Published - Sep 2020

Bibliographical note

Funding Information:
The cases described were in the context of research studies supported by the United States United States Fogarty International Center (K01TW010268, R25TW009345), National Institute of Neurological Disorders and Stroke (R01NS086312), National Institute of Allergy and Infectious Diseases (T32AI055433), United Kingdom Medical Research Council/Wellcome Trust/Department for International Development (MRC MR/M007413/1) and Grand Challenges Canada (S4-0296-01).

Funding Information:
The cases described were in the context of research studies supported by the United States United States Fogarty International Center ( K01TW010268 , R25TW009345 ), National Institute of Neurological Disorders and Stroke ( R01NS086312 ), National Institute of Allergy and Infectious Diseases ( T32AI055433 ), United Kingdom Medical Research Council / Wellcome Trust / Department for International Development ( MRC MR/M007413/1 ) and Grand Challenges Canada ( S4-0296-01 ).

Publisher Copyright:
© 2020 The Author(s)

Keywords

Cryptococcal meningitis
Cryptococcosis
HIV
Lateral flow assay
Prozone effect

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abstract = "There is an increasing recognition of patients presenting with cryptococcal meningitis despite having a negative CSF cryptococcal antigen (CrAg). In this report, we describe three cases of patients with advanced immunosuppression who presented to hospital with “false negative” CSF cryptococcal antigen, two of whom had a positive fungal culture. We describe the challenge of CSF-CrAg negative cryptococcal meningitis and explore ways to overcome this challenge using newer diagnostic techniques.",

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AU - Rhein, Joshua

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“False negative” CSF cryptococcal antigen with clinical meningitis: Case reports and review of literature

Abstract

Bibliographical note

Keywords

UN SDGs

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