Fatty acid amide hydrolase substrate specificity

Dale L. Boger; Robert A. Fecik; Jean E. Patterson; Hiroshi Miyauchi; Matthew P. Patricelli; Benjamin F. Cravatt

doi:10.1016/S0960-894X(00)00528-X

Fatty acid amide hydrolase substrate specificity

Dale L. Boger, Robert A. Fecik, Jean E. Patterson, Hiroshi Miyauchi, Matthew P. Patricelli, Benjamin F. Cravatt

Medicinal Chemistry

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Abstract

Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	2613-2616
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(00)00528-X
State	Published - Dec 4 2000

Bibliographical note

Funding Information:
We gratefully acknowledge the financial support of the Skaggs Institute for Chemical Biology, National Institutes of Health (CA42056, D.L.B.; MH58542, B.F.C.), fellowships for R.A.F. (American Cancer Society 576211) and M.P.P. (National Science Foundation), and the postdoctoral sabbatical leave of H.M. sponsored by Sumitomo Pharmaceuticals.

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abstract = "Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH. (C) 2000 Elsevier Science Ltd.",

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AU - Boger, Dale L.

AU - Fecik, Robert A.

AU - Patterson, Jean E.

AU - Miyauchi, Hiroshi

AU - Patricelli, Matthew P.

AU - Cravatt, Benjamin F.

N1 - Funding Information: We gratefully acknowledge the financial support of the Skaggs Institute for Chemical Biology, National Institutes of Health (CA42056, D.L.B.; MH58542, B.F.C.), fellowships for R.A.F. (American Cancer Society 576211) and M.P.P. (National Science Foundation), and the postdoctoral sabbatical leave of H.M. sponsored by Sumitomo Pharmaceuticals.

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AB - Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers. FAAH hydrolyzes a range of fatty acid amides, and the present study examines the relative rates of hydrolysis of a variety of natural and unnatural fatty acid primary amide substrates using pure recombinant rat FAAH. (C) 2000 Elsevier Science Ltd.

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Fatty acid amide hydrolase substrate specificity

Abstract

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