Finding better protein engineering strategies

Romas J. Kazlauskas; Uwe T. Bornscheuer

doi:10.1038/nchembio0809-526

Finding better protein engineering strategies

Romas J. Kazlauskas, Uwe T. Bornscheuer

Synthetic Biology and Biotechnology Division

Research output: Contribution to journal › Comment/debate › peer-review

189 Scopus citations

Abstract

Protein improvement strategies today involve widely varying combinations of rational design with random mutagenesis and screening. To make further progress-defined as making subsequent protein engineering problems easier to solve-protein engineers must critically compare these strategies and eliminate less effective ones.

Original language	English (US)
Pages (from-to)	526-529
Number of pages	4
Journal	Nature Chemical Biology
Volume	5
Issue number	8
DOIs	https://doi.org/10.1038/nchembio0809-526
State	Published - Aug 2009

Bibliographical note

Funding Information:
U.T.B. thanks the German Research Foundation (DFG, Grant Bo1862/4-1) and R.J.K. the US National Science Foundation (CHE-0616560) for financial support.

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Finding better protein engineering strategies

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