Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia

Eun jin Cheon; Alie G. Male; Bingchen Gao; Bhim M. Adhikari; Jesse T. Edmond; Stephanie M. Hare; Aysenil Belger; Steven G. Potkin; Juan R. Bustillo; Daniel H. Mathalon; Judith M. Ford; Kelvin O. Lim; Bryon A. Mueller; Adrian Preda; Daniel O'Leary; Gregory P. Strauss; Anthony O. Ahmed; Paul M. Thompson; Neda Jahanshad; Peter Kochunov; Vince D. Calhoun; Jessica A. Turner; Theo G.M. van Erp

doi:10.1016/j.pscychresns.2023.111597

Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia

Eun jin Cheon, Alie G. Male, Bingchen Gao, Bhim M. Adhikari, Jesse T. Edmond, Stephanie M. Hare, Aysenil Belger, Steven G. Potkin, Juan R. Bustillo, Daniel H. Mathalon, Judith M. Ford, Kelvin O. Lim, Bryon A. Mueller, Adrian Preda, Daniel O'Leary, Gregory P. Strauss, Anthony O. Ahmed, Paul M. Thompson, Neda Jahanshad, Peter KochunovVince D. Calhoun, Jessica A. Turner, Theo G.M. van Erp

Psychiatry & Behavioral Sciences

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Abstract

This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.

Original language	English (US)
Article number	111597
Journal	Psychiatry Research - Neuroimaging
Volume	329
DOIs	https://doi.org/10.1016/j.pscychresns.2023.111597
State	Published - Mar 2023

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Publisher Copyright:
© 2023

Keywords

ALFF
Avolition
Negative symptoms

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Cheon, E. J., Male, A. G., Gao, B., Adhikari, B. M., Edmond, J. T., Hare, S. M., Belger, A., Potkin, S. G., Bustillo, J. R., Mathalon, D. H., Ford, J. M., Lim, K. O., Mueller, B. A., Preda, A., O'Leary, D., Strauss, G. P., Ahmed, A. O., Thompson, P. M., Jahanshad, N., ... van Erp, T. G. M. (2023). Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia. Psychiatry Research - Neuroimaging, 329, Article 111597. https://doi.org/10.1016/j.pscychresns.2023.111597

Cheon, EJ, Male, AG, Gao, B, Adhikari, BM, Edmond, JT, Hare, SM, Belger, A, Potkin, SG, Bustillo, JR, Mathalon, DH, Ford, JM, Lim, KO , Mueller, BA, Preda, A, O'Leary, D, Strauss, GP, Ahmed, AO, Thompson, PM, Jahanshad, N, Kochunov, P, Calhoun, VD, Turner, JA & van Erp, TGM 2023, 'Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia', Psychiatry Research - Neuroimaging, vol. 329, 111597. https://doi.org/10.1016/j.pscychresns.2023.111597

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title = "Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia",

abstract = "This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.",

keywords = "ALFF, Avolition, Negative symptoms",

author = "Cheon, {Eun jin} and Male, {Alie G.} and Bingchen Gao and Adhikari, {Bhim M.} and Edmond, {Jesse T.} and Hare, {Stephanie M.} and Aysenil Belger and Potkin, {Steven G.} and Bustillo, {Juan R.} and Mathalon, {Daniel H.} and Ford, {Judith M.} and Lim, {Kelvin O.} and Mueller, {Bryon A.} and Adrian Preda and Daniel O'Leary and Strauss, {Gregory P.} and Ahmed, {Anthony O.} and Thompson, {Paul M.} and Neda Jahanshad and Peter Kochunov and Calhoun, {Vince D.} and Turner, {Jessica A.} and {van Erp}, {Theo G.M.}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = mar,

doi = "10.1016/j.pscychresns.2023.111597",

language = "English (US)",

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AU - Cheon, Eun jin

AU - Male, Alie G.

AU - Gao, Bingchen

AU - Adhikari, Bhim M.

AU - Edmond, Jesse T.

AU - Hare, Stephanie M.

AU - Belger, Aysenil

AU - Potkin, Steven G.

AU - Bustillo, Juan R.

AU - Mathalon, Daniel H.

AU - Ford, Judith M.

AU - Lim, Kelvin O.

AU - Mueller, Bryon A.

AU - Preda, Adrian

AU - O'Leary, Daniel

AU - Strauss, Gregory P.

AU - Ahmed, Anthony O.

AU - Thompson, Paul M.

AU - Jahanshad, Neda

AU - Kochunov, Peter

AU - Calhoun, Vince D.

AU - Turner, Jessica A.

AU - van Erp, Theo G.M.

PY - 2023/3

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AB - This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.

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Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia

Abstract

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Keywords

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