Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

Jenna R. Rosinski; Lauren E. Raasch; Patrick Barros Tiburcio; Meghan E. Breitbach; Phoenix M. Shepherd; Keisuke Yamamoto; Elaina Razo; Nicholas P. Krabbe; Mason I. Bliss; Alexander D. Richardson; Morgan A. Einwalter; Andrea M. Weiler; Emily L. Sneed; Kerri B. Fuchs; Xiankun Zeng; Kevin K. Noguchi; Terry K. Morgan; Alexandra J. Alberts; Kathleen M. Antony; Sabrina Kabakov; Karla K. Ausderau; Ellie K. Bohm; Julia C. Pritchard; Rachel V. Spanton; James N. Ver Hoove; Charlene B.Y. Kim; T. Michael Nork; Alex W. Katz; Carol A. Rasmussen; Amy Hartman; Andres Mejia; Puja Basu; Heather A. Simmons; Jens C. Eickhoff; Thomas C. Friedrich; Matthew T. Aliota; Emma L. Mohr; Dawn M. Dudley; David H. O’Connor; Christina M. Newman

doi:10.1371/journal.ppat.1011282

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

Jenna R. Rosinski, Lauren E. Raasch, Patrick Barros Tiburcio, Meghan E. Breitbach, Phoenix M. Shepherd, Keisuke Yamamoto, Elaina Razo, Nicholas P. Krabbe, Mason I. Bliss, Alexander D. Richardson, Morgan A. Einwalter, Andrea M. Weiler, Emily L. Sneed, Kerri B. Fuchs, Xiankun Zeng, Kevin K. Noguchi, Terry K. Morgan, Alexandra J. Alberts, Kathleen M. Antony, Sabrina KabakovKarla K. Ausderau, Ellie K. Bohm, Julia C. Pritchard, Rachel V. Spanton, James N. Ver Hoove, Charlene B.Y. Kim, T. Michael Nork, Alex W. Katz, Carol A. Rasmussen, Amy Hartman, Andres Mejia, Puja Basu, Heather A. Simmons, Jens C. Eickhoff, Thomas C. Friedrich, Matthew T. Aliota, Emma L. Mohr, Dawn M. Dudley, David H. O’Connor, Christina M. Newman

Veterinary and Biomedical Sciences

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Abstract

In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.

Original language	English (US)
Article number	e1011282
Journal	PLoS pathogens
Volume	19
Issue number	3
DOIs	https://doi.org/10.1371/journal.ppat.1011282
State	Published - Mar 2023

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This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

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Rosinski, J. R., Raasch, L. E., Tiburcio, P. B., Breitbach, M. E., Shepherd, P. M., Yamamoto, K., Razo, E., Krabbe, N. P., Bliss, M. I., Richardson, A. D., Einwalter, M. A., Weiler, A. M., Sneed, E. L., Fuchs, K. B., Zeng, X., Noguchi, K. K., Morgan, T. K., Alberts, A. J., Antony, K. M., ... Newman, C. M. (2023). Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus. PLoS pathogens, 19(3), Article e1011282. https://doi.org/10.1371/journal.ppat.1011282

Rosinski, JR, Raasch, LE, Tiburcio, PB, Breitbach, ME, Shepherd, PM, Yamamoto, K, Razo, E, Krabbe, NP, Bliss, MI, Richardson, AD, Einwalter, MA, Weiler, AM, Sneed, EL, Fuchs, KB, Zeng, X, Noguchi, KK, Morgan, TK, Alberts, AJ, Antony, KM, Kabakov, S, Ausderau, KK, Bohm, EK, Pritchard, JC, Spanton, RV, Ver Hoove, JN, Kim, CBY, Nork, TM, Katz, AW, Rasmussen, CA, Hartman, A, Mejia, A, Basu, P, Simmons, HA, Eickhoff, JC, Friedrich, TC, Aliota, MT, Mohr, EL, Dudley, DM, O’Connor, DH & Newman, CM 2023, 'Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus', PLoS pathogens, vol. 19, no. 3, e1011282. https://doi.org/10.1371/journal.ppat.1011282

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abstract = "In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.",

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AU - Shepherd, Phoenix M.

AU - Yamamoto, Keisuke

AU - Razo, Elaina

AU - Krabbe, Nicholas P.

AU - Bliss, Mason I.

AU - Richardson, Alexander D.

AU - Einwalter, Morgan A.

AU - Weiler, Andrea M.

AU - Sneed, Emily L.

AU - Fuchs, Kerri B.

AU - Zeng, Xiankun

AU - Noguchi, Kevin K.

AU - Morgan, Terry K.

AU - Alberts, Alexandra J.

AU - Antony, Kathleen M.

AU - Kabakov, Sabrina

AU - Ausderau, Karla K.

AU - Bohm, Ellie K.

AU - Pritchard, Julia C.

AU - Spanton, Rachel V.

AU - Ver Hoove, James N.

AU - Kim, Charlene B.Y.

AU - Nork, T. Michael

AU - Katz, Alex W.

AU - Rasmussen, Carol A.

AU - Hartman, Amy

AU - Mejia, Andres

AU - Basu, Puja

AU - Simmons, Heather A.

AU - Eickhoff, Jens C.

AU - Friedrich, Thomas C.

AU - Aliota, Matthew T.

AU - Mohr, Emma L.

AU - Dudley, Dawn M.

AU - O’Connor, David H.

AU - Newman, Christina M.

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N2 - In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about the impacts of gestational African-lineage ZIKV infections. Given high human immunodeficiency virus (HIV) burdens in regions where African-lineage ZIKV circulates, we evaluated whether pregnant rhesus macaques infected with simian immunodeficiency virus (SIV) have a higher risk of African-lineage ZIKV-associated birth defects. Remarkably, in both SIV+ and SIV- animals, ZIKV infection early in the first trimester caused a high incidence (78%) of spontaneous pregnancy loss within 20 days. These findings suggest a significant risk for early pregnancy loss associated with African-lineage ZIKV infection and provide the first consistent ZIKV-associated phenotype in macaques for testing medical countermeasures.

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ER -

Frequent first-trimester pregnancy loss in rhesus macaques infected with African-lineage Zika virus

Abstract

Bibliographical note

UN SDGs

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