TY - JOUR
T1 - Functional maturation in visual pathways predicts attention to the eyes in infant rhesus macaques
T2 - Effects of social status
AU - Ford, Aiden
AU - Kovacs-Balint, Zsofia A.
AU - Wang, Arick
AU - Feczko, Eric
AU - Earl, Eric
AU - Miranda-Domínguez, Óscar
AU - Li, Longchuan
AU - Styner, Martin
AU - Fair, Damien
AU - Jones, Warren
AU - Bachevalier, Jocelyne
AU - Sánchez, Mar M.
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/4
Y1 - 2023/4
N2 - Differences in looking at the eyes of others are one of the earliest behavioral markers for social difficulties in neurodevelopmental disabilities, including autism. However, it is unknown how early visuo-social experiences relate to the maturation of infant brain networks that process visual social stimuli. We investigated functional connectivity (FC) within the ventral visual object pathway as a contributing neural system. Densely sampled, longitudinal eye-tracking and resting state fMRI (rs-fMRI) data were collected from infant rhesus macaques, an important model of human social development, from birth through 6 months of age. Mean trajectories were fit for both datasets and individual trajectories from subjects with both eye-tracking and rs-fMRI data were used to test for brain-behavior relationships. Exploratory findings showed infants with greater increases in FC between left V1 to V3 visual areas have an earlier increase in eye-looking before 2 months. This relationship was moderated by social status such that infants with low social status had a stronger association between left V1 to V3 connectivity and eye-looking than high status infants. Results indicated that maturation of the visual object pathway may provide an important neural substrate supporting adaptive transitions in social visual attention during infancy.
AB - Differences in looking at the eyes of others are one of the earliest behavioral markers for social difficulties in neurodevelopmental disabilities, including autism. However, it is unknown how early visuo-social experiences relate to the maturation of infant brain networks that process visual social stimuli. We investigated functional connectivity (FC) within the ventral visual object pathway as a contributing neural system. Densely sampled, longitudinal eye-tracking and resting state fMRI (rs-fMRI) data were collected from infant rhesus macaques, an important model of human social development, from birth through 6 months of age. Mean trajectories were fit for both datasets and individual trajectories from subjects with both eye-tracking and rs-fMRI data were used to test for brain-behavior relationships. Exploratory findings showed infants with greater increases in FC between left V1 to V3 visual areas have an earlier increase in eye-looking before 2 months. This relationship was moderated by social status such that infants with low social status had a stronger association between left V1 to V3 connectivity and eye-looking than high status infants. Results indicated that maturation of the visual object pathway may provide an important neural substrate supporting adaptive transitions in social visual attention during infancy.
KW - Brain-behavior associations
KW - Infant development
KW - Nonhuman primate
KW - Resting state fMRI
KW - Social attention
KW - Visual object pathway
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U2 - 10.1016/j.dcn.2023.101213
DO - 10.1016/j.dcn.2023.101213
M3 - Article
C2 - 36774827
AN - SCOPUS:85147856746
SN - 1878-9293
VL - 60
JO - Developmental Cognitive Neuroscience
JF - Developmental Cognitive Neuroscience
M1 - 101213
ER -