Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis

Karin R. Vevang; Lin Zhang; Alex E. Grill; Dorothy K. Hatsukami; Ellen Meier; Sarah O Nomura; Kim Robien; Lisa A. Peterson

doi:10.1021/acs.chemrestox.2c00412

Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis

Karin R. Vevang, Lin Zhang, Alex E. Grill, Dorothy K. Hatsukami, Ellen Meier, Sarah O Nomura, Kim Robien, Lisa A. Peterson

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Abstract

Humans are exposed to furan, a toxicant and possible human carcinogen, through multiple sources including diet and tobacco smoke. The urinary metabolites of furan are derived from the reaction of its toxic metabolite with protein nucleophiles and are biomarkers of exposure and potential harm. An established isotopic dilution liquid-chromatography mass spectrometry method was used to measure these biomarkers in urine from users of e-cigarettes, cannabis, and/or combustible tobacco with/without reduced nicotine levels. Amounts of furan mercapturic acid metabolites were higher in these individuals relative to nonsmokers, indicating that they may be at risk for potential furan-derived toxicities.

Original language	English (US)
Pages (from-to)	157-161
Number of pages	5
Journal	Chemical research in toxicology
Volume	36
Issue number	2
DOIs	https://doi.org/10.1021/acs.chemrestox.2c00412
State	Published - Feb 20 2023

Bibliographical note

Funding Information:
This research was supported by funds from the National Institute of Drug Abuse (K01DA043413 Loan Repayment Program and T32DA007097, E.M.), the National Institute of Environmental Health Sciences (R01ES10577 and U2CES026533, L.A.P.), the National Cancer Institute (T32 CA13267, S.O.N.) the Masonic Cancer Center Forster Family Chair in Cancer Prevention (D.H.), and the Masonic Cancer Center (L.A.P.). In addition, it was funded by grants from the University of Minnesota Institute on the Environment (K.R.) and a Hawley Award from the University of Minnesota School of Public Health for dissertation research (S.O.N.). The Masonic Cancer Center Analytical Biochemistry Shared Resource is funded in part by the National Cancer Institute (P30 CA-077598).

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© 2023 American Chemical Society.

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abstract = "Humans are exposed to furan, a toxicant and possible human carcinogen, through multiple sources including diet and tobacco smoke. The urinary metabolites of furan are derived from the reaction of its toxic metabolite with protein nucleophiles and are biomarkers of exposure and potential harm. An established isotopic dilution liquid-chromatography mass spectrometry method was used to measure these biomarkers in urine from users of e-cigarettes, cannabis, and/or combustible tobacco with/without reduced nicotine levels. Amounts of furan mercapturic acid metabolites were higher in these individuals relative to nonsmokers, indicating that they may be at risk for potential furan-derived toxicities.",

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note = "Funding Information: This research was supported by funds from the National Institute of Drug Abuse (K01DA043413 Loan Repayment Program and T32DA007097, E.M.), the National Institute of Environmental Health Sciences (R01ES10577 and U2CES026533, L.A.P.), the National Cancer Institute (T32 CA13267, S.O.N.) the Masonic Cancer Center Forster Family Chair in Cancer Prevention (D.H.), and the Masonic Cancer Center (L.A.P.). In addition, it was funded by grants from the University of Minnesota Institute on the Environment (K.R.) and a Hawley Award from the University of Minnesota School of Public Health for dissertation research (S.O.N.). The Masonic Cancer Center Analytical Biochemistry Shared Resource is funded in part by the National Cancer Institute (P30 CA-077598). Publisher Copyright: {\textcopyright} 2023 American Chemical Society.",

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Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis

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